A paired transcriptomic analysis of Parkinson's disease patients revealed eighteen differentially expressed blood genes and broad downregulation of translational, bioenergetic, ...
Expansion microscopy reveals that cellular stress dismantles and reorganizes the mammalian nucleolus through biophysical shifts and deacidification driven directly by ...
A transcriptomic reanalysis of weaned piglets found that higher post-weaning growth correlates with an ileal shift in ribosome biogenesis gene ...
Researchers established a quantitative single-molecule imaging methodology combining fluorescence lifetime measurements and pulsed interleaved excitation FRET across DNA standards, encapsulated ...
A pan-cancer database analysis and cell-based study indicates that elevated RIOK2 expression correlates with poor prognosis in hepatocellular carcinoma and ...
Researchers analyzed ribosome biogenesis gene activity across single-cell and bulk transcriptomes to stratify metastatic melanoma prognosis and identify FKBP4 as ...
An integrated pan-cancer analysis of public multi-omics data across 33 tumor types revealed that elevated FBL expression correlates with advanced ...
Icariin, the main bioactive component of Herba Epimedii, reversed nucleolar stress markers in Aβ25–35-treated BV2 cells and APP/PS1 mice, according ...
A preclinical study reports that the EGFR inhibitor osimertinib and the XPO1 inhibitor selinexor synergistically deplete c-MYC and trigger nucleolar ...
A combined bioinformatics and rat-model study identifies AKT1, JAK2, TNF, STAT1, and miR-135a as candidate molecular targets of treadmill training ...
In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...
An integrative Arabidopsis study mapped chloroplast rRNA modifications and linked stepwise modification during ribosome biogenesis to rRNA maturation, chloroplast ribosome ...
Researchers have developed the first selective inhibitors of the NVL ATPase, blocking 60S ribosomal subunit assembly to activate p53 and ...
A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...
New research reveals that Leishmania parasites survive antimony treatment through active transcriptome remodeling, a transient persister state that may pave ...
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
In a groundbreaking study published in Nature Microbiology, scientists have uncovered a striking new mechanism by which Candida albicans, a ...
