Tag: pyroptosis

In a preclinical study, saikosaponin A accelerated wound closure in diabetic mice and was associated with suppressed macrophage pyroptosis and ...

A mouse study finds that depleting gut microbiota or neutralizing IL-17A protects cerebrovascular pericytes and the blood-brain barrier in an ...

A new review frames the cGAS-STING DNA-sensing pathway as a self-reinforcing inflammatory amplifier that links cellular damage to whole-joint remodeling ...

A correspondence in Blood Research raises four methodological concerns about a study linking HERV-K102 envelope deletion to pyroptosis in acute ...

A new study links the ER chaperone HSP90B1 to cardiomyocyte pyroptosis, NF-κB/NLRP3 signaling, and M1-like macrophage polarization after myocardial infarction.

A review in Molecular Biology Reports describes how pro-inflammatory forms of regulated cell death, including ferroptosis, pyroptosis and necroptosis, contribute ...

A new study in mice and cardiomyocytes shows that TRPM7 promotes ischemia-reperfusion heart injury through a CaMKII/DDX3X/NLRP3 pathway that drives ...

A new review proposes an 'acute storm versus chronic siege' framework distinguishing how acute and chronic liver disease injure the ...

A new study shows that the immune sensor NLRC4 acts as a tumour suppressor in lung adenocarcinoma by restoring PTEN ...

A preclinical study reports that the Tibetan formula Zang-Si-Wei and its core component ellagic acid reduced inflammation and lung damage ...

A preclinical study reports that the herbal formula Xiaoai Jiedu recipe suppresses PINK1-mediated mitophagy and activates NLRP3 inflammasome signaling in ...

Laboratory experiments linked Streptococcus anginosus culture supernatant to NLRP3-related macrophage activation and tumor-associated cellular changes, while an observational tissue analysis ...

A review finds that HIV-1 suppresses MAVS-dependent antiviral signaling in myeloid cells while distinct IFI16 and CARD8 pathways can promote ...

A mouse immune-cell study links inflammation-induced chimeric RNA formation to a functional fusion protein that sharpens the trade-off between bacterial ...

A 2026 review identifies pyroptosis as a context-dependent pathway in intestinal and systemic inflammation and evaluates inflammasome, caspase and gasdermin-directed ...

Panax notoginseng saponins promoted diabetic wound repair in mice by preserving 11,12-EET, protecting mitochondria and suppressing inflammatory macrophage pyroptosis.

Researchers at Sun Yat-sen University show that blocking the cGAS-STING pathway and the NLRP3 inflammasome reduces inflammatory cell death and ...

A three-cohort transcriptomic reanalysis finds extracellular-matrix remodeling as the most reproducible molecular signature of frozen shoulder, while pyroptosis, ferroptosis, and ...

A new transcriptomic and cell study links the G3BP1 stress granule axis to pyroptosis in cochlear hair cells, revealing a ...

A new review in the Journal of Advanced Research maps how sepsis-driven lactate accumulation chemically rewrites proteins through lactylation, tipping ...