Host Genomics Could Reshape How Doctors Diagnose Immune Disorders and Treat Infections
More than 30 experts outline how patients' germline genomes could improve infectious disease care, from detecting rare immune disorders early ...
Tag: Precision Medicine
Pneumonia may lead to sepsis through a failing immune boundary, researchers argue
A perspective in Critical Care argues that pneumonia-associated sepsis should be understood as a multidimensional syndrome driven by loss of ...
Genetic Testing Could Reshape Emergency Prescribing, but the Evidence Is Not There Yet
A new perspective argues that pharmacogenomic testing could improve emergency department prescribing, but no randomized controlled trials have yet tested ...
Gut Microbiome Gene Score Predicts Rheumatoid Arthritis Drug Response in New Study
A computational study built a gut microbiota–metabolite–host gene score that stratified rheumatoid arthritis patients into two molecular subtypes and predicted ...
Gene Dosage Decoded: New Review Maps Path to Precision Therapy for CMT1A
A new narrative review maps the genetic architecture, regulatory landscape and emerging precision therapies for Charcot-Marie-Tooth disease type 1A.
Dexmedetomidine Faces a Reality Check as Evidence Points to Conditional Benefits
A new editorial argues that recent large trials have failed to show broad benefits for the sedative dexmedetomidine, while suggesting ...
Lab-on-a-chip screens drug combinations for pediatric leukemia before treatment begins
A microfluidic lab-on-a-chip developed in Atlanta measures how a child's leukemia cells respond to drug combinations from a single sample, ...
Synovitis severity may steer JAK inhibitor response in difficult-to-treat rheumatoid arthritis
A small prospective biopsy study suggests high-grade synovitis may identify difficult-to-treat rheumatoid arthritis patients who respond better to JAK inhibitors ...
Beyond Blood Sugar: How Type 2 Diabetes Research Is Being Rewritten
A new narrative review argues that chronic inflammation, gut microbiota dysbiosis, and mitochondrial dysfunction are reshaping type 2 diabetes care ...
Organic Nanoparticles Emerge as Safer Rivals to Inorganic Theranostic Platforms
A new review argues that organic and hybrid nanomaterials can match or exceed the diagnostic and therapeutic performance of inorganic ...
Blood protein signatures may hint at which rheumatoid arthritis drug will work first
An exploratory study derived drug-specific protein signatures from rheumatoid arthritis immune cells ex vivo and found they moderately discriminated treatment-specific ...
Massive Genetic Map Pinpoints 1,757 Heart Rhythm Variants Linked to Sudden Death
An international team led by Vanderbilt Health researchers has created a functional map of 1,757 genetic variants that can trigger ...
Genes, Environment and Multi-Omics Maps Reshape How IPF Is Understood and Predicted
A wide-ranging review links genetic variation, multi-omics mechanisms and environmental exposures in idiopathic pulmonary fibrosis, proposing a multi-gene risk score ...
Can Genes and Gut Microbes Predict Who Responds to Semaglutide for Liver Disease?
A new review builds an evidence-tiered framework for predicting GLP-1 therapy response in fatty liver disease using host genotype and ...
Precision Medicine in Schizophrenia: Systematic Review of Biomarkers in African Populations
A systematic review of twenty-eight studies across seven African countries synthesizes evidence on blood-based and genetic biomarkers for precision medicine ...
CYP17A1 Mutations Linked to Steroid Defects in Polycystic Ovary Syndrome Study
An in silico and genotyping study identified 22 pathogenic CYP17A1 mutations and modeled how two heme-binding domain variants may impair ...
AI-Designed 3D-Printed Hydrogels Move Toward Repairing Skin and Bone
A new review maps how artificial intelligence is reshaping 3D-printed hydrogel scaffolds for skin and bone regeneration, while flagging the ...
Mitochondrial dysfunction emerges as a shared thread across neurological disease
A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid ...
Antibody-Drug Conjugates Extend Survival in Triple-Negative Breast Cancer, Meta-Analysis Finds
A systematic review and meta-analysis of six studies covering 2,479 patients found that antibody-drug conjugates significantly improved progression-free and overall ...
Why Almost No Machine Learning Models Ever Reach the Hospital Bedside
An editorial in Frontiers in Medicine argues that the vast majority of clinical machine-learning models never reach patients, with fewer ...
