Exome and Array Data Combined Rival Whole-Genome Sequencing for Most Pharmacogenes
Combining whole-exome sequencing with imputed genotyping array data matched whole-genome sequencing results for 25 of 33 pharmacogenes in UK Biobank ...
Tag: Precision Medicine
First Placebo-Controlled Trial Will Test Prednisone for Drug-Induced Liver Injury
The DILICORT trial, the first randomized double-blind placebo-controlled study of prednisone in acute idiosyncratic drug-induced liver injury, will enroll sixty ...
Genomics Moves From Variant Discovery to Precision Diagnosis Across Rare and Common Disease
A sweeping editorial on a 2024–2025 research collection describes how long-read sequencing, newborn screening, population genomics, and functional studies are ...
ANCA vasculitis research shifts toward personalised medicine as new studies probe immune origins and treatment risks
Eleven new studies on ANCA-associated vasculitis reveal transient pandemic-era incidence shifts, qualitative B-cell immune signatures, checkpoint biomarkers predicting rituximab failure, ...
Rebuilding the gut in miniature: next-generation models decode enteric pathogenesis
A new review explains how air-liquid interface cultures and gut-on-a-chip systems recreate the human intestinal mucosa, exposing previously hidden infection ...
NCI funds Ohio State study of AML treatment resistance
A five-year National Cancer Institute grant will support efforts to identify biomarkers that predict response and relapse in older adults ...
Review Proposes Biomarker-Based rTMS Strategy for Stroke
A review proposes a biomarker-based framework to reconcile conflicting theories of post-stroke recovery, guiding precision brain stimulation based on individual ...
Do Weight-Loss Drugs Eat Muscle? Landmark Review Weighs In on SGLT2 Inhibitors and Incretin Therapies
A new narrative review finds that SGLT2 inhibitors and incretin-based therapies preferentially reduce fat while lean tissue loss generally stays ...
ERC Grant Targets Sex-Based Biology Behind Women’s Heart Disease
A €1.5 million ERC Starting Grant project at Aarhus University will combine laboratory experiments, imaging and computational modelling to study ...
Collagen-Targeted MRI Agent Spots Tiny Lung Tumors and Hidden Metastases in Preclinical Tests
A collagen-targeted protein MRI contrast agent developed at Georgia State University detected invasive lung tumors and multi-organ metastases as small ...
Late-life blood pressure decline signals brain vessel damage in women
An autopsy study of 2,033 older adults links faster late-life systolic blood pressure decline to more severe brain arteriolosclerosis and ...
Counting Molecular Mismatches: HLA Eplet Analysis Moves Kidney Transplant Care Toward Precision Immune Risk Assessment
A new narrative review finds that quantifying structural HLA differences between donor and recipient predicts antibody-mediated rejection risk and may ...
Mitochondrial Dysfunction Emerges as a Shared Network Behind Osteoarthritis Pain
A review proposes that mitochondrial dysfunction across cartilage, synovium, subchondral bone and neural compartments forms a shared pathological network linking ...
Blocking ERG Protein Radiosensitizes ERG-Positive Prostate Cancers by Disabling DNA Repair
New research shows that inhibiting the ERG protein, overproduced in about half of prostate cancers, selectively impairs DNA double-strand break ...
AI Subtyping Suggests Polycystic Ovarian Syndrome Is Four Distinct Conditions
A review argues that polycystic metabolic ovarian syndrome is best understood as four biologically distinct subtypes identified through multi-omics data ...
Review proposes network-level GPCR control against multiple aging processes
A peer-reviewed literature review proposes that rebalancing G protein-coupled receptor signaling across multiple pathways could influence several aging-related processes, but ...
Molecular obesity therapies advance, but precision prescribing remains largely unproven
A 2026 review finds that multi-agonist obesity drugs can produce substantial weight loss, but biomarker and pharmacogenomic tools are not ...
BabyMERIT Trial to Test Trametinib for Severe Infantile Hypertrophic Cardiomyopathy
The NIH-funded BabyMERIT trial will test trametinib in 25 infants with severe hypertrophic cardiomyopathy associated with Noonan syndrome and related ...
Beyond generalist AI: purpose-built foundation models for transplantation
A 2026 Perspective proposes a five-part design and deployment roadmap for foundation models that jointly represent donor, recipient and graft ...
Brazilian cancer biobank targets precision prevention for diverse population
A Hospital de Amor biobank has collected nearly 40,000 blood samples from more than 4,000 Brazilians to develop cancer risk ...
