Small trials, big approvals: FDA data reveal how companion diagnostics reshaped cancer drug development
A survey of 87 FDA-approved cancer drugs linked to companion diagnostic assays found that most were cleared on the basis ...
Tag: Precision Medicine
Neuroimaging has mapped psychosis biology but still cannot guide treatment
A new editorial argues that reproducible brain-behavior mappings, not more case-control differences, are the missing link for precision therapeutics in ...
CLL treatment shifts toward fixed-duration and MRD-guided targeted regimens
A new review describes how chronic lymphocytic leukemia treatment has shifted from chemoimmunotherapy to targeted, fixed-duration, and MRD-guided regimens guided ...
AI in kidney care shows promise but clinical proof still lags behind
A narrative review finds AI models across nephrology achieve strong predictive performance, yet prospective validation and evidence of patient benefit ...
AI model flags which severe asthma patients will not benefit from biologics
A multinational retrospective study of 801 severe asthma patients built a Random Forest model that doubled specificity in identifying likely ...
RAS Inhibitor Daraxonrasib Redefines Pancreatic Cancer Treatment After FDA Approval
A phase 3 trial of the pan-RAS inhibitor daraxonrasib doubled median overall survival in previously treated metastatic pancreatic cancer, prompting ...
AI Framework Aims to Transform Helicobacter pylori Care from Diagnosis to Vaccines
A new review proposes a five-module artificial intelligence framework linking endoscopic diagnosis, genomic resistance prediction, vaccine design and digital adherence ...
Nanomedicine Aims to Sharpen Colorectal Cancer Diagnosis and Treatment
A new open-access review in Cancer Nanotechnology surveys how nanomaterials could improve colorectal cancer diagnosis, targeted therapy, and personalized theranostics.
Diet scores boost genetic prediction of BMI and diabetes in Native Hawaiians
A study of 14,346 Native Hawaiians shows that combining trans-ancestry polygenic scores with machine-learning dietary scores substantially improves BMI prediction, ...
Sputum Proteomics Reveals Two Molecular Endotypes in COPD Exacerbations
A proteomic study of induced sputum identified a ciliary-enriched and a keratinization-dominant endotype in acute COPD exacerbations, with an immunoglobulin-based ...
Lipid Unsaturation Patterns Split Lupus Patients into Distinct Groups
Serum lipid profiling of 121 lupus patients revealed reduced glycerophospholipid acyl-chain unsaturation that separates patients into subgroups linked to disease ...
Italian Researchers Propose National AI Network for Obesity Monitoring
Italian researchers have proposed OBESI-NET, a conceptual national AI-supported ecosystem for obesity surveillance and precision medicine that has not yet ...
Stroke begins years earlier: vascular dysfunction offers a window for prevention
A new review argues that stroke is the endpoint of progressive vascular failure and that translational models can uncover biomarkers ...
Lab-Grown Bone Marrow Models Reshape How Myeloma Is Studied
A new review maps how 3D bone marrow models, from spheroids to bioprinted and organ-on-chip systems, are being used to ...
Pneumonia-driven ARDS emerges as biologically distinct syndrome demanding tailored care
A narrative review argues that pneumonia-driven ARDS is a biologically distinct, heterogeneous form of respiratory failure in which pathogen burden, ...
Metabolites Emerge as Signaling Hubs Driving Diabetic Kidney Disease
A new review reframes diabetic kidney disease as a network-level disease driven by metabolites acting as signaling mediators, biomarkers and ...
Sepsis is not one disease: how subphenotypes could reshape precision therapy
A narrative review argues that sepsis is a biologically heterogeneous syndrome whose reproducible subphenotypes may eventually guide targeted treatment, though ...
New roadmap outlines latest therapeutic progress for systemic sclerosis
A new narrative review in BMC Rheumatology summarises current best practice for managing systemic sclerosis, highlighting cellular therapies, multi-omics and ...
Recalibrating Polygenic Risk Scores to Local Data Sharpens Disease Risk Prediction
A new framework recalibrates published polygenic risk scores to local biobank data, improving risk prediction for coronary artery disease, breast ...
Light therapy in dentistry moves toward precision dosimetry, review argues
A narrative review argues that photobiomodulation's strongest evidence lies in oral mucositis prevention, while inconsistent dosimetry and reporting standards hold ...
