Synthetic organelle records fleeting gene expression in single human cells
A single-protein synthetic organelle called the recordanelle preserves transient RNA expression records in human cells for at least five days, ...
Tag: phase separation
Cellular Droplets Reveal How a Growth Factor Signal Drives Skin Pigmentation
A new cell study shows that the metabolic signaling protein IRS-1 promotes melanin production through droplet-forming phase separation, linking growth ...
Phase-Separating Amine Solvents Could Slash the Energy Cost of CO2 Capture
A new review argues that amine-based biphasic absorbents, which split into CO2-rich and CO2-lean phases after capturing carbon dioxide, can ...
Catalyst Failure Mechanisms Guide More Efficient Sulfur Conversion
An experimental Xiamen University study identifies phase separation and transition-metal migration as catalyst failure pathways and uses the findings to ...
Phase Separation in Exsolution Catalysts Begins in the First Atomic Layer
In situ scanning tunneling microscopy reveals that nickel segregation and partial phase separation in heavily doped strontium titanate thin films ...
Subtle Shape Shifts, Not Misfolding: How FUS Mutations Drive ALS
A computational study shows that ALS-linked FUS mutations cause disease through subtle, site-specific changes in protein flexibility and molecular recognition ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
Cytomegalovirus Hijacks Host Chromatin Remodeler MORC2 to Fuel Viral Genome Repair
A new PLOS Pathogens study shows that human cytomegalovirus induces and recruits the host chromatin remodeler MORC2 to viral replication ...
Plants Build Their Own Sunscreen From Protein Condensates Under Intense Light
A Nature Plants highlight describes how singlet oxygen triggers MBS1 protein condensates that shield chloroplasts from excess light, and how ...
Mutations Give RNA Droplets Their Own Genes, Vacuoles and Movement
Researchers have shown that RNA droplets trap their own DNA templates, and that even low rates of mutation produce stable ...
Heat Stress Drives a Fertility Protein Into Worm Germ Cell Granules, Revealing a New Stress Response
New research in C. elegans shows that the conserved stress granule protein GTBP-1 reorganizes into P-body-associated granules during heat stress ...
Dunes Follow a Hidden Physics: Young Coastal Dune Landscapes Self-Organize Like Phase-Separating Fluids
New research shows that young coastal dune landscapes self-organize through phase-separation physics, revealing local tipping points beyond which damage to ...
Spray-Coated Self-Stratifying Fibers Supercharge Triboelectric Nanogenerators
South Korean researchers have developed a one-step spray-coating method that self-assembles stratified PDMS/P(VDF-TrFE) fibrous composites for high-performance, durable triboelectric nanogenerators ...
HDAC1 Condensation Links to Temozolomide Response in Glioblastoma
In the ongoing battle against glioblastoma, one of the most aggressive forms of brain cancer, the standard therapy temozolomide has ...
DDX6 Phase Separation Drives Chemoresistance, Metabolic Flexibility
In a groundbreaking study poised to redefine our understanding of cancer biology and therapeutic resistance, researchers have unveiled the intricate ...
mRNAs Coordinate Condensation-Prone Protein Stability
In the intricate environment of the cell nucleus, nuclear speckles have long been recognized as critical hubs for RNA processing ...
Not just a phase for RNAS
Phenomenon known as "phase separation" allows an RNA to tightly control the activity of a protein that regulates neurodegeneration and ...
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