Mouse study maps how porcine circovirus type 2d reshapes immune cells
A mouse study found that PCV2d infection activated lymphocyte subsets on distinct schedules, triggered thymic T-cell apoptosis, shifted memory T-cell ...
Tag: PD-1
Checkpoint Inhibitors Show Promise for People With HIV, but Africa Remains Excluded
A new review finds checkpoint inhibitors are safe and effective for virologically suppressed people with HIV, while sub-Saharan Africa remains ...
GMP kit enables ready-to-use zirconium-89 pembrolizumab PET imaging agent
Researchers have formulated a GMP-quality kit for preparing a zirconium-89 labelled pembrolizumab PET imaging agent, with preclinical studies supporting safety ...
Leukemia inhibitory factor shifts immune checkpoint gene expression in abortion-prone mice
A mouse study finds that leukemia inhibitory factor alters the expression of several immune checkpoint-related genes in the decidua of ...
Stress and cancer immunotherapy: distress linked to poorer checkpoint inhibitor outcomes
A new review finds that pretreatment psychological distress is consistently associated with poorer outcomes after immune checkpoint inhibitor therapy, while ...
Tumor Protein RNF128 Linked to Immune Resistance in Bladder Cancer
A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
T cells in AML are not uniformly dysfunctional, researchers argue in new analysis
A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...
Liver Injury Affects One in Eight Patients on Immune Checkpoint Inhibitors in Real-World Study
A retrospective study of 682 patients in Tianjin found 12.17 percent developed liver injury on immune checkpoint inhibitor therapy, with ...
Checkpoint inhibitors improve survival in pMMR metastatic colorectal cancer meta-analysis
A meta-analysis of six randomized trials found that adding PD-1/PD-L1 inhibitors to chemotherapy was associated with longer progression-free and overall ...
Research report: PF chemotherapy combined with a PD-1/CTLA-4 bispecific antibody as first-line treatment in patients with recurrent/metastatic head and neck squamous cell carcinoma: a prospective, single-arm, phase II clinical study
A small, single-arm phase II study found a 56.3% response rate with first-line cadonilimab plus PF chemotherapy in 16 patients ...
U.S. trial tests ivonescimab for advanced biliary tract cancer
A National Cancer Institute-funded phase 2/3 trial will test ivonescimab plus chemotherapy against standard chemoimmunotherapy in U.S. patients with advanced ...
MerTK links dexamethasone to weakened antiviral immunity in chronic LCMV infection
A mouse study found that MerTK largely mediated dexamethasone-associated suppression of antiviral CD8+ T cells and increased LCMV dissemination during ...
Menopause Marks a Turning Point in How the Immune System Ages, Study Finds
A large Chinese cohort study shows that lymphocyte subsets in women undergo a pronounced reconfiguration around menopause, with B cell ...
Combining Targeted Drugs With Immunotherapy Shows Uneven Results in Advanced Lung Cancer, Analysis Finds
A Bayesian network meta-analysis of 19 studies finds that EGFR inhibitors combined with PD-L1 blockade show a strong response signal ...
One in Eight Monitored Patients Show Thyroid Damage After PD-1 Immunotherapy
Immune checkpoint inhibitors have transformed the outlook for many patients with advanced cancer, but the same immune reawakening that lets ...
Nivolumab Delivers Remarkable Remission in Late Liver Metastasis Recurrence of Advanced Malignant Melanoma
A Japanese case report documents a remarkable sustained response to nivolumab in a patient whose stage III melanoma recurred as ...
PD-1/PD-L1 Inhibitors Show Greater-Than-Additive Synergy With Conventional Therapies in Esophageal Squamous Cell Carcinoma
A new narrative review synthesizes clinical trial evidence showing that combining PD-1/PD-L1 immune checkpoint inhibitors with chemotherapy, radiotherapy, and surgery ...
Cancer’s Master Switch: New Map Reveals How Tumors Outsmart Immunotherapy
A sweeping new review in Molecular Cancer maps the PD-1/PD-L1 axis from immune evasion mechanisms to next-generation therapeutics, offering a ...
How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
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