Resveratrol Mitigates Diabetic Kidney Glucolipid Damage via AKT and HIF-1α
A study combining network pharmacology with rat models and human cell assays reveals that resveratrol alleviates diabetic nephropathy by suppressing ...
Tag: network pharmacology
Computational Study Models Tazemetostat Binding in Thyroid Cancer
A computational study in Clinical Epigenetics evaluates tazemetostat's predicted binding to five hub targets in ARID1A-deficient anaplastic thyroid cancer, highlighting ...
Soursop fruit compounds show computational promise against Alzheimer’s protein
A computational study of Annona muricata fruit phytochemicals identifies spathulenol, caryophyllene oxide and bornyl acetate as the strongest predicted binders ...
Triglycerides Linked Causally to Gout Risk Across Genetic and Observational Analyses
A multi-method investigation suggests triglycerides independently drive gout risk through immune signaling pathways while high-density lipoprotein cholesterol exhibits no independent ...
Plant extract shows antimalarial, anticancer and anti-inflammatory activity in lab tests
A hydroethanolic extract of Erycibe paniculata showed antimalarial, anticancer and anti-inflammatory effects in cell-based laboratory tests with no cytotoxicity observed.
Study Uncovers Antioxidant Polyphenol Biosynthesis and Targets in Polygonatum Cyrtonema
Researchers evaluated Polygonatum cyrtonema samples across five geographical origins to identify key antioxidant polyphenols and their biosynthetic genes.
Snow Lotus Compound β-Sitosterol Shields Skin Cells From UVB Barrier Damage
Researchers combined chemical profiling and cell experiments to identify β-sitosterol from Saussureae involucratae as a compound that reduced UVB-induced oxidative ...
Formononetin Suppresses Ferroptosis to Protect the Diabetic Heart via PPARγ
A study in Cell Biology and Toxicology reports that formononetin, a bioactive constituent of Gegen Qinlian capsule, attenuated cardiac injury ...
Traditional Chinese Medicine Shows Promise Against Radiation-Induced Intestinal Injury, But Evidence Falls Short
A comprehensive review finds that Traditional Chinese Medicine formulas and compounds modulate multiple pathological processes in radiation enteropathy, yet clinical ...
Eugenol-Infused Alginate-Chitosan Scaffold Shows Promise for Bone Repair in Lab Tests
Researchers combined the clove-derived compound eugenol with a natural polymer-ceramic scaffold and found improved mechanical strength, sustained drug release and ...
Traditional Chinese Formula Shows Antifibrotic Effects Through PI3K/AKT Pathway
A traditional Chinese medicine formula reduced liver fibrosis in rat and cell models by down-regulating the PI3K/AKT signaling pathway, according ...
Tryptanthrin from Yinhuang Gargle Emerges as Anti-Inflammatory Candidate Against Periodontitis
A combined computational and cell-based study identifies Tryptanthrin, a constituent of a traditional Chinese medicine gargle, as a candidate anti-inflammatory ...
Computational Map Splits Atropine’s Myopia Targets From Dry Eye Pathways
A computational study identified 57 shared and 19 myopia-specific atropine targets, linking inflammatory remodelling pathways to both myopia control and ...
Traditional Chinese Formula Zhizhu Decoction Eases IBS-Like Symptoms in Rats
A network pharmacology and rat study found that the traditional Chinese formula Zhizhu Decoction improved constipation-predominant IBS-like symptoms, intestinal barrier ...
Yeast fermentation products rank first for boosting feed intake in cattle
A network meta-analysis ranked Saccharomyces cerevisiae fermentation products first among 22 interventions for increasing dry matter intake in cattle, with ...
Traditional Chinese Medicine Compounds Trigger Cancer Cell Ferroptosis via TP53
Researchers report that ursolic acid and Anhydroicaritin, key components of the traditional formula Fuzheng Yiai, bind and upregulate TP53 to ...
Juniper extract nanoparticles show antimicrobial and anticancer activity in lab tests
Egyptian researchers loaded Juniperus phoenicea leaf extract into nanostructured lipid carriers that showed enhanced antibacterial activity against Acinetobacter baumannii and ...
Two Collagen Peptides from Pig Skin Shield Skin Cells from UV Damage
Researchers identified two porcine skin collagen peptides, FGPYGF and GPPSGGFG, that protected UVB-damaged human keratinocytes in cell culture by acting ...
Kaempferol Eases Muscle Wasting in Mice With Cancer Cachexia
A study combining bibliometric mining, network pharmacology and mouse experiments identified the plant flavonoid kaempferol as a candidate compound against ...
Pinocembrin Shows Dual Kidney Protection in Diabetic Mouse and Cell Models
A new study reports that the propolis-derived flavonoid pinocembrin reduced kidney injury in diabetic db/db mice and high-glucose-treated kidney cells ...
