Researchers designed and synthesized twelve novel triazole-benzoyl azaglycinamide hybrid compounds, identifying a dinitro derivative with notable in vitro cytotoxicity against ...
Researchers demonstrated that the natural pentacyclic triterpene uvaol inhibits blood vessel formation by targeting key kinase enzymes in computational, enzymatic, ...
A new study links smoking-associated cadmium to JNK2 activation in neurons, driving mitochondrial dysfunction and APP accumulation relevant to Alzheimer's ...
An integrative hypothesis-generating analysis identified SPP1 and extracellular matrix remodeling as candidate features linking bisphenol A exposure to an immunosuppressive ...
A newly published chemical and pharmacological investigation has detailed the isolation, structural elucidation, and antimicrobial evaluation of a distinct chromone ...
A systematic review and computational study indicates that Nigella sativa compounds may cooperatively target penicillin-binding protein 2a and disrupt membranes ...
A multi-cohort transcriptomic study identified shared genetic biomarkers and immune mechanisms connecting atherosclerosis and lung adenocarcinoma, providing new models for ...
A structure-based molecular docking study evaluated nine phytochemicals from Siddha-associated medicinal plants against the SARS-CoV-2 main protease, identifying distinct polar ...
Researchers combined chemical profiling and cell experiments to identify β-sitosterol from Saussureae involucratae as a compound that reduced UVB-induced oxidative ...
An in silico docking study of 128 compounds identified remdesivir, adefovir, zidovudine and several plant-derived molecules as candidates for further ...
A pull-down and docking study in Trypanosoma brucei identified candidate TbRRM1 protein interactors and pinpointed a predicted binding platform spanning ...
Researchers profiled Magnolia officinalis bark extract and evaluated computational interactions between its candidate constituents and apoptosis-associated proteins relevant to chemotherapy ...
A computational study in Medical Oncology presents a six-gene prognostic signature for pancreatic ductal adenocarcinoma that links triptolide-associated biology to ...
Researchers found that the natural compound liensinine binds ATG9B to modulate AKT/mTOR signalling and reduce excessive autophagy in PCOS cell ...
Scientists isolated three novel cytochalasins from an oyster-derived fungus, with two compounds curbing nitric oxide production in mouse microglial cells.
Researchers from Cameroon and Germany propose ten guiding principles for building sustainable computational drug discovery programs in low- and middle-income ...
A comparative study finds that the protease SP02 from Brevibacterium luteolum dehairs goat skins at lower temperatures and penetrates skin ...
Researchers combined the clove-derived compound eugenol with a natural polymer-ceramic scaffold and found improved mechanical strength, sustained drug release and ...
A traditional Chinese medicine formula reduced liver fibrosis in rat and cell models by down-regulating the PI3K/AKT signaling pathway, according ...
A newly synthesized guanidinium cadmium chloride crystal killed A549 lung and MCF-7 breast cancer cells at lower concentrations than cisplatin ...
