Tag: Innate immunity

A new review explains how neutrophil, complement, and barrier defects reshape antibiotic activity in immunocompromised patients with resistant bacterial infections.

Autophagy in alveolar macrophages restrains IL-1α production, and blocking it primes innate immunity that speeds clearance of bacterial and viral ...

A case-control study in Iraq finds markedly elevated LL-37 and TLR-9 levels in rheumatoid arthritis patients alongside pro-atherogenic lipid shifts ...

BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.

Researchers found that the immune sensor MDA5 moves to the cell surface during lung injury to clear extracellular RNA, and ...

A new review frames the cGAS-STING DNA-sensing pathway as a self-reinforcing inflammatory amplifier that links cellular damage to whole-joint remodeling ...

A bone marrow chimera study in mice shows that deleting the CLEC4E receptor in cardiac resident cells, rather than in ...

A new study in Myeloid Cells reports that the vaccine adjuvant AS01 induces trained immunity in human monocytes and slows ...

A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...

Mice injected with bacterial endotoxin showed suppressed STAT1 signaling in splenocytes stimulated with interferon-gamma a day later, a new study ...

Complete deletion of the ALS-linked gene TBK1 suppresses microglial activation and extends disease duration in SOD1-ALS model mice, a new ...

A new study identifies MARK3 as a kinase that promotes type I interferon production by phosphorylating GEF-H1 and activating the ...

The newly described Panoptes bacterial immune system detects phage evasion by sensing the loss of nucleotide signals that sponge proteins ...

New laboratory research shows that macrophages from people with cystic fibrosis are intrinsically impaired in controlling the virulent rough morphotype ...

A laboratory study of pediatric and adult liver organoids found higher Omicron viral RNA accumulation and a stronger innate immune ...

A nested case-control study associated distinct serum protein trajectories with rapid SARS-CoV-2 IgG waning after breakthrough infection in older vaccinated ...

New mouse research shows that type I interferon signaling restricts early Borrelia burgdorferi expansion by boosting macrophage uptake and killing, ...

A time-resolved study of Salmonella-infected mouse macrophages shows the bacterium's SPI-1 injectisome suppresses the TLR4-dependent transcriptional response during the first ...

A 2026 evidence review links OAS1, an interferon-induced double-stranded-RNA sensor, to HIV-1 restriction, persistence, immune regulation and neurological outcomes without ...

A laboratory study of primary human lung fibroblasts finds that senescent fibrotic cells from idiopathic pulmonary fibrosis lungs activate antiviral ...