Tag: Innate immunity

A new review maps how RNA- and DNA-sensing innate immune pathways determine whether cardiotropic viral infection resolves or progresses to ...

Mouse infection experiments show that Mycobacterium tuberculosis remains difficult for innate immunity to clear across ultra-low-dose, microbiota-primed, and Legionella-primed models.

A review finds that HIV-1 suppresses MAVS-dependent antiviral signaling in myeloid cells while distinct IFI16 and CARD8 pathways can promote ...

A 2026 review finds that hepatitis E virus enters cells through overlapping receptor networks and counters innate immunity through activities ...

A Lactobacillus brevis cell-free supernatant reduced several inflammation-associated genes in DSS-stimulated HT-29 cells while increasing, decreasing or leaving unchanged other ...

A prospective study found that moderate pediatric burns were associated with reduced monocyte HLA-DR expression but heightened early whole-blood TNF-α ...

A mouse study found that inherited mitochondrial DNA variation was associated with age-dependent retinal respiratory-chain remodeling, mitochondrial DNA damage and ...

A 2026 review examines how the host RNA-binding protein PTBP1 can support or restrict viral translation, replication and immune-related signaling ...

Researchers report that Y RNAs on the surface of human monocytes bind extracellular histones and amplify TLR2/TLR4-driven inflammatory signaling, with ...

New research shows that the transcription factor C/EBPβ normally restrains an inflammatory interferon and TNF-α program that, when unleashed in ...

RNA sequencing reveals that persistent canine distemper virus infection reshapes immune, angiogenic, and metabolic gene expression in canine histiocytic sarcoma ...

New research identifies the RIG-I, MDA5, MAVS, and IRF3 signaling axis as the primary pathway by which human cells detect ...

New research shows the African swine fever virus protein QP509L suppresses innate immunity by simultaneously blocking STING trafficking and STAT1-dependent ...

A new review argues that sugar-based signaling through Siglec receptors and complement Factor H forms a hidden regulatory layer determining ...

A new review details how the transcriptional repressor PRDM1 orchestrates natural killer cell maturation, effector function, and tumor suppression, with ...

New research shows oral isotretinoin suppresses five key pro-inflammatory cytokines at both gene and protein levels in acne patients, with ...

Researchers have catalogued the Toll immune pathway genes of the potato psyllid and shown that the insect mounts haplotype-specific responses ...

A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...

A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...

New research in Nature Communications shows that the viral RNA sensor MDA5 helps tumors evade immunity, and that disabling it ...