Researchers using single-cell and spatial genomics have mapped cardiac inflammaging in mice, discovering that age-related inflammation and fibrosis concentrate primarily ...
A systematic review of 37 human studies reveals that persistent immune activation, gut barrier disruption, and altered T-cell differentiation drive ...
A narrative review argues that age-related chronic inflammation, macrophage-driven immune signalling and blood-brain barrier dysfunction may shift the concentration-effect relationship ...
A study of older adults in the GAINS cohort found higher IL-2 levels in mild frailty and showed inflammatory markers ...
A new review synthesizes preclinical evidence that the CaMKIIδ kinase integrates calcium dysregulation, inflammation, autophagy failure, mitochondrial decline and DNA ...
A study of 176 middle-aged men found that masculine physical traits and testosterone did not independently predict biological aging markers, ...
A post-hoc analysis of the ASPREE trial found that daily low-dose aspirin did not preserve intrinsic capacity in older adults ...
A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains ...
A cross-sectional study of 303 older Italian adults with cardiometabolic diseases found malnutrition in 39.9%, sarcopenia in 30.9%, and frequent ...
A new review links age-related gut microbiome changes to chronic disease and evaluates microbiome-targeted therapies that still need clinical validation.
A rat study finds that chronic high-fat diet feeding leaves liver organoid-forming regenerative cells locked in a senescence-like state with ...
A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...
A comprehensive review maps how genetics, inflammation, metabolism, lifestyle, and environment converge on the cardiovascular system to shape human lifespan—and ...
An integrated single-cell atlas of more than 375,000 endothelial cells from 12 human tissues identifies conserved transcriptional hallmarks of vascular ...
AFAR awarded eight early career investigators nearly $1.3 million for one- to two-year projects on planned investigations into mechanisms of ...
A small randomized trial sub-study found no significant individual-gene changes after 18 months of metformin in older adults with age-related ...
A proteomic study of 28 healthy ovaries from women aged 50 to 75 reveals that the organ undergoes progressive molecular ...
Age-related hearing loss, or presbycusis, has long been viewed as an inevitable consequence of wear and tear on the delicate ...
A new review in Frontiers in Microbiomes argues that aging and disease reflect the collapse of an ancient symbiotic network ...
A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...
