Tag: induced pluripotent stem cells

A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...

Patient-derived astrocytes and human brain slice models reveal water-transport, immune and cytoskeletal abnormalities linked to CDKL5 loss.

Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact ...

Researchers corrected two SOD1 mutations linked to familial ALS in human induced pluripotent stem cells, achieving roughly 10% correction with ...

Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking ...

A new human cell model shows that astrocytes lacking the prion protein display increased reactivity markers and mitochondrial abnormalities, yet ...

An integrative ATAC-seq and RNA-seq study of induced endothelial cells from capillary malformation patients identifies inflammation-associated chromatin remodeling and distal ...

A new review finds stem cell and extracellular vesicle therapies show encouraging preclinical results for Alzheimer's disease, but published clinical ...

Lab-grown blood-brain barrier cells from adults with ADHD carrying PARK2 copy number variations show small genotype-linked changes, while culture duration ...

A transient 4CL treatment during reprogramming yields human iPSCs with enhanced mesodermal, endodermal, and pancreatic differentiation capacity.

A methylation comparison of human gingival fibroblasts, their derived iPSCs and an embryonic stem-cell reference found broad pluripotent-state convergence alongside ...

Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation ...

A review proposes combining engineered peroxisomal catalytic materials with patient-derived iPSC neural models while emphasizing that the integrated approach remains ...

An in vitro study combining human atrial cardiomyocytes, fibroblasts and intermittent tachypacing reproduced selected electrical, calcium-handling and fibrotic changes associated ...

A sold-out Kyoto symposium brought together scientists, clinicians, and innovators reviewing 20 years of iPSC research across development models, disease ...

A new review maps how patient-derived induced pluripotent stem cells and three-dimensional vascular and neurovascular organoids are transforming Moyamoya disease ...

A new review highlights how induced pluripotent stem cells are being engineered into immune cells, cancer vaccines, and tumor models ...

Endothelial cells derived from women with PCOS harbor a latent mitochondrial defect that hyperglycemia unmasks, and blocking the enzyme myeloperoxidase ...

Every cell in the human body carries a hidden archive of its past. Now researchers at Erasmus University Medical Center ...

Researchers have identified the interferon-stimulated protein IFIT3 as a highly dysregulated centromere-proximal protein in fetal Down syndrome cells, showing that ...