Cold-exposed frog livers rewire metabolism toward glucose production and fat storage
A five-day cold exposure at 5 °C triggers hyperglycemia and a coordinated transcriptional shift in the Xenopus laevis liver toward ...
Tag: glycolysis
Blood proteins reveal right ventricular remodeling after tetralogy of Fallot repair
A small proof-of-concept study found that adolescents with repaired tetralogy of Fallot and moderate-severe right ventricular dilation on cardiac MRI ...
ZEB1-TEAD1 partnership keeps heart cells fueled and functioning
A mouse study in Nature Communications shows that the transcription factor ZEB1 works with TEAD1 to activate metabolic genes sustaining ...
Synthetic enzyme redirects metabolism and slows melanoma xenografts
A synthetic enzyme produced pyruvate inside cancer-cell mitochondria, increased oxidative metabolism, altered growth-related gene expression and slowed human melanoma xenografts ...
Glycolysis Diverges from Its Transcripts in Human Hypertrophic Cardiomyopathy
A multi-omics analysis of human hypertrophic cardiomyopathy found suppressed glycolytic transcription but divergent enzyme-protein changes, while oxidative pathways declined more ...
Stem Cell Exosomes Carry a MicroRNA That Halts Kidney Scarring
Chronic kidney disease is a slow-motion catastrophe. Millions of people live with kidneys that are quietly being replaced by scar ...
Novel Ginseng-Derived Compound Shields the Liver From Acetaminophen Overdose by Damping HIF1α-Driven Glycolysis
A newly synthesized ginsenoside-lipoic acid hybrid called OCLA protected mice from acetaminophen-induced liver injury by directly targeting HIF1α and suppressing ...
Kidney Cancer’s Metabolic Rewiring Exposes New Drug Targets
A review in Genes & Diseases maps how VHL loss drives metabolic reprogramming in clear cell renal cell carcinoma and ...
TRIP13 shields a key metabolic enzyme from destruction, helping colorectal cancer adapt and resist chemotherapy
TRIP13 protects LDHA from FBXW7-mediated degradation, sustaining a lactate-driven antioxidant program that helps colorectal cancer cells adapt to hypoxia and ...
Inflammatory Fatty Acid Drains Kidney Cells’ Energy Supply, Worsening Podocyte Damage
New research shows that arachidonic acid released during infection worsens podocyte kidney injury by disrupting PKM2-linked glycolytic metabolism and mitochondrial ...
Hidden RNA Switch Drives Airway Remodeling Through a Metabolic FUS/HK2 Axis
A new study reveals that the lncRNA HOTAIR drives airway smooth muscle remodeling by stabilizing HK2 mRNA through the RNA-binding ...
Cancer Cells Run on a Metabolic Hybrid Engine, and Surgeons May Soon Map It
A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...
Tiny RNA Molecule May Explain Why Some People Resist Tuberculosis Infection
A new PLOS Pathogens study finds that the microRNA-1246 regulates macrophage lipid metabolism and helps explain why some household contacts ...
Sugar Molecules, Not Size, Keep Key Metabolic Enzyme Working Under Stress
A new study shows that sugar-based chemical interactions, rather than molecular crowding size, help the glycolytic enzyme PFKP stay active ...
Sticky Nanosheets Deliver Sustained Hydrogen to Rejuvenate Aging Testes in Mice
Researchers have developed a bioadhesive nanoplatform that releases hydrogen slowly inside the scrotum, restoring sperm production in aged mice by ...
Onion Extract and Diabetes Drug Show Promise Against Common Gut Parasite in Lab Study
Egyptian researchers found that metronidazole, metformin, and onion extract all suppress Blastocystis growth in lab cultures by disrupting the parasite's ...
How Exercise Reprograms Glucose Metabolism to Fight Osteoporosis
A new review reveals that exercise protects against osteoporosis by reprogramming how bone cells burn glucose, linking glycolysis, lactate signaling, ...
Lab-Grown Retinas Mirror the Real Thing, but Their Metabolism Lags Behind
A new metabolomic study shows that mouse retinal organoids share 148 of 166 detected metabolites with native retina, yet reveal ...
Lactate emerges as both warning sign and driver of kidney injury after heart surgery
A new iScience study combining machine learning on over 6,500 patient records with rat and cell experiments shows that lactate ...
Newborns with congenital diaphragmatic hernia show hyperactive but inefficient mitochondria in endothelial cells
Endothelial cells from newborns with congenital diaphragmatic hernia display hyperactive but inefficient mitochondria, linking cellular energy dysfunction to pulmonary vascular ...
