Resistant Hypertension Linked to Premature Vascular Aging and PTEN-AKT Cellular Senescence
A multi-stage study reveals that resistant hypertension is linked to cellular senescence and vascular stiffening driven by dysregulated PTEN and ...
Tag: Endothelial dysfunction
ITGA5 speeds diabetic wound healing by easing mitochondrial iron overload
A new study reports that restoring the integrin subunit ITGA5 accelerated wound closure in diabetic mice by protecting endothelial mitochondria ...
Review Highlights Epigenetic and Metabolic Remodeling in Pulmonary Arterial Hypertension
A scientific review details how disrupted metabolic pathways regulate epigenetic remodeling in pulmonary vascular cells during pulmonary arterial hypertension.
Pre-Existing Endothelial Dysfunction Dampens Aerobic Fitness Gains in Middle-Aged Adults
A study of middle-aged adults shows that pre-existing endothelial dysfunction significantly weakens the cardiorespiratory fitness gains achieved through an eight-week ...
Immune Complexes of SARS-CoV-2 RNA and Nucleocapsid Drive Inflammation
A PLOS Pathogens study shows that SARS-CoV-2 RNA, nucleocapsid protein and anti-N IgG1 form immune complexes that trigger inflammatory cytokines ...
ESM-1 shows non-linear link to cardiovascular risk in type 2 diabetes
A cross-sectional study of 56 type 2 diabetes patients and 57 matched controls found higher ESM-1 levels and ASCVD risk ...
Stroke begins years earlier: vascular dysfunction offers a window for prevention
A new review argues that stroke is the endpoint of progressive vascular failure and that translational models can uncover biomarkers ...
Extracellular vesicles carry liver signals that reshape the vasculature
A new review maps how extracellular vesicles mediate liver-cardiovascular crosstalk, finding the strongest evidence for liver-to-vascular signaling and calling for ...
Microvascular Disease May Link Diabetes to Heart Failure With Preserved Ejection Fraction
A new review argues that heart failure with preserved ejection fraction in diabetes may represent a cardiac manifestation of diabetic ...
Pneumonia may lead to sepsis through a failing immune boundary, researchers argue
A perspective in Critical Care argues that pneumonia-associated sepsis should be understood as a multidimensional syndrome driven by loss of ...
Endothelial TXNIP emerges as a driver of pulmonary vascular remodeling
A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...
Fatty liver disease leaves early fingerprints in the retina, OCTA review finds
A systematic review of seven OCTA studies finds that patients with metabolic liver disease show consistent thinning of the deep ...
IL-35 Cytokine Restores Obesity-Damaged Vessels via STAT3-MAPK/ERK-eNOS Axis
The anti-inflammatory cytokine IL-35 reverses obesity-impaired vasodilation in mice and human endothelial cells by activating the STAT3-MAPK/ERK-eNOS axis, restoring eNOS ...
Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Computer model finds timing and dose govern simulated endothelial repair
A multiscale simulation found that endothelial repair depended on early, moderate AKT activation and on balancing local nitric oxide production ...
Maternal high-fat diet before pregnancy may program offspring heart disease risk
A new review synthesizes evidence that maternal high-fat diet before and during pregnancy may program offspring coronary artery disease risk ...
How Broken Body Clocks and Iron-Driven Cell Death May Fuel Hypertension
A new review proposes that circadian disruption may lower the threshold for iron-driven ferroptotic cell death in blood vessels and ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
Sirtuin 1 emerges as the molecular switch linking cellular senescence to heart failure
A new review argues that the longevity enzyme sirtuin 1 sits at the molecular crossroads between cellular senescence and heart ...
ApoE4 May Raise Risk of Cognitive Decline From Small Vessel Disease, Review Finds
A new narrative review argues that ApoE4 acts as a context-dependent susceptibility modifier in cerebral small vessel disease rather than ...
POPULAR NEWS
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Two C3 Gene Variants Reveal Functional Independence Between Extracellular and Intracellular Forms of Complement C3
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Nearly Half of Stroke Patients in Africa and Asia Show Low HDL Cholesterol
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German heat-health plans rarely evaluated due to political and structural barriers, study finds
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Carb Quality Beats Glycemic Index in Sperm DNA Study