Machine Learning Identifies Shared Targets Between Diabetes and Aggressive Breast Cancer
A computational transcriptomics and machine learning study identified four shared regulatory genes and two candidate repurposed drugs linking type 2 ...
Tag: Drug repurposing
Immune System Digital Twins Identify Drug Combination to Prevent Preterm Birth
Stanford Medicine researchers used AI-driven digital twins of the maternal immune system to identify an aspirin and lansoprazole combination that ...
Dysregulated Potassium Channels Reveal Potential Drug Repurposing Candidates for Long COVID
A transcriptomic meta-analysis reveals dysregulated potassium channels in long COVID patients, highlighting existing approved medications as potential candidates for repurposing.
Deep Learning Model Accelerates Drug Target Screening and Repurposing Opportunities
Researchers have developed a deep learning architecture combining transformers and convolutional neural networks to predict drug-target affinities and accelerate virtual ...
Nifuratel Targets Proton Motive Force to Fight Staphylococcus epidermidis Infections
Nifuratel shows potent bactericidal activity against Staphylococcus epidermidis by disrupting the proton motive force, offering a new strategy for treating ...
Trial Protocol Tests Empagliflozin in Duchenne Cardiomyopathy
A new phase 2a trial protocol aims to evaluate the pharmacokinetics and safety of empagliflozin in children with Duchenne muscular ...
Darunavir Precursor Enhances Tamoxifen Response in Breast Cancer
A study in Cell Biology and Toxicology shows that a darunavir-analogue precursor enhances tamoxifen response in breast cancer by inducing ...
Knowledge Graph Framework Uncovers Drug Repurposing Targets for Aplastic Anaemia
Researchers developed a computational knowledge graph combining literature mining and biological databases to identify potential drug repurposing candidates and molecular ...
Virtual Screen Spotlights Antiviral Drugs and Plant Compounds Against SARS-CoV-2 Proteins
An in silico docking study of 128 compounds identified remdesivir, adefovir, zidovudine and several plant-derived molecules as candidates for further ...
Methylene blue tames septic shock by blocking neutrophil pyroptosis through FASN
A new study reports that methylene blue protects mice from septic shock by upregulating FASN in neutrophils, which suppresses NLRP3-mediated ...
Lab-grown gallbladder cancer organoids reproduce tumor genetics and predict chemotherapy response
Patient-derived gallbladder cancer organoids faithfully reproduced tumor genetics and showed drug sensitivities that tracked with patient survival in a preliminary ...
Redox drugs for Huntington’s disease: why strong preclinical promise keeps failing in trials
A new narrative review finds that antioxidant and mitochondria-targeted compounds show consistent benefits in Huntington's disease models but have repeatedly ...
Machines Join the Hunt for New Schistosomiasis Drugs
A new review argues that machine learning can speed the search for schistosomiasis drugs only if paired with standardized, high-throughput ...
Cystic Fibrosis Drug Ivacaftor Eases Lung Scarring in Mice by Rejuvenating Aging Air Sac Cells
A new mouse study shows the approved cystic fibrosis drug ivacaftor reduced pulmonary fibrosis by suppressing senescence in alveolar type ...
Vinpocetine Eases Lung Inflammation in Mice by Damping Pentraxin 3
A mouse study of mixed granulocytic asthma suggests the drug vinpocetine reduces airway inflammation by lowering levels of the immune ...
Drug Repurposing Candidate Ebselen Boosts Mitochondrial Function Across Disease Models
A preclinical study reports that the organoselenium compound ebselen improved mitochondrial respiration, ATP production and exercise capacity in yeast, human ...
Osimertinib and Selinexor Team Up Against Aggressive T-Cell Leukemia in Preclinical Study
A preclinical study reports that the EGFR inhibitor osimertinib and the XPO1 inhibitor selinexor synergistically deplete c-MYC and trigger nucleolar ...
Integrated chemical profiling and lipidomics reveal that Mailuoning oral liquid alleviates diet-induced MASLD via PPARα-mediated lipid homeostasis and COX-2 inhibition, with identification of potential active constituents
A traditional Chinese medicine formula that has been used clinically in China for over three decades has now been studied ...
Approved Drugs Dissolve Mutant Polymerase Aggregates and Restore Motor Function in Mice
Two already approved drugs, diltiazem and sulbactam, dissolved mutant POLGA aggregates and restored mitochondrial DNA replication and motor function in ...
Ambrisentan ameliorates methotrexate nephrotoxicity through modulation of RhoA/ROCK and PI3K/MDM2-associated signaling: network pharmacology-guided discovery and in vivo confirmation
A rat study found that the pulmonary hypertension drug ambrisentan, given before and during methotrexate exposure, protected the kidneys by ...
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