UVA Launches Six Million Dollar Fund to Accelerate New Medicine Pipeline
Philanthropic gifts totaling six million dollars have established the UVA Biotech Innovation Fund to support translational drug discovery programs at ...
Tag: Drug development
Small trials, big approvals: FDA data reveal how companion diagnostics reshaped cancer drug development
A survey of 87 FDA-approved cancer drugs linked to companion diagnostic assays found that most were cleared on the basis ...
LC–MS/MS emerges as the workhorse of modern drug development
A new review maps how liquid chromatography–tandem mass spectrometry now quantifies drugs, metabolites, genotoxic impurities and proteins across every stage ...
Boosting the Body’s Own Muscle Repair Offers New Hope for Muscular Dystrophy
A new review argues that drugs enhancing the body's own muscle regeneration, exemplified by the approved HDAC inhibitor Givinostat, could ...
Natural Products Target Mitochondria and Macrophage Crosstalk in Kidney Disease Review
A new review examines how mitochondrial dysfunction and macrophage inflammation interact in diabetic nephropathy and whether natural products can modulate ...
Oral GLP-1 therapies reshape obesity treatment, review finds
A new review in Cardiovascular Diabetology describes how FDA-approved oral GLP-1 receptor agonists such as semaglutide and orforglipron are expanding ...
Machine learning predicts human oral drug bioavailability from animal data
A machine learning pipeline trained on 192 FDA-approved compounds predicts human oral bioavailability with an R2 of 0.766, outperforming previous ...
HDAC isoform targeting offers a precision route to treating neurodegeneration
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
Tau PET Imaging Shows Faster Tau Buildup Tracks Faster Decline in PSP
A longitudinal PET study using the QST-developed tracer florzolotau found that patients with progressive supranuclear palsy whose brain tau accumulated ...
Experimental Compounds Curb Glioblastoma Cell Invasion in Tissue Slice Models
In ex vivo xenograft tissue slice co-cultures, indole analogs and the aryl sulfonamide AqB011 potently inhibited glioblastoma cell invasion into ...
Beyond Calcium: Imaging Reveals the Hidden Fibrotic Side of Aortic Valve Disease
A new review argues that calcific aortic valve disease is two diseases in one, and that imaging of both fibrous ...
Phase 3 Trial: New Drug Cuts Endometrial Cancer Death Risk
A phase 3 trial shows sacituzumab tirumotecan significantly lowers the risk of cancer progression and death in women with recurrent ...
Dietary Phytochemicals Show Promise Against Neuroinflammation, but Bioavailability Barriers Remain
A review argues that dietary phytochemicals with robust preclinical anti-neuroinflammatory effects should be prioritized for bioavailability optimization and standardized preclinical ...
Transcriptional CDK Inhibitors Emerge as Dual Weapons Against Bone Metastases
A new review argues that transcriptional CDK inhibitors, especially CDK9 blockers, could simultaneously target oncogenic transcription in metastatic tumor cells ...
Protein Maps Chart Antibodies Across Mouse Brain Tissue
A mouse-brain study generated maps of monoclonal antibodies and more than 6,000 proteins across tissue sections, demonstrating a preclinical method ...
Review Finds Fungal Compounds Promising, but Skin-Cancer Trials Remain Limited
A review finds that fungal compounds can suppress tumour growth, alter immunity and limit metastasis in skin-cancer models, but manufacturing, ...
NIH Grant Funds First Human Trials of On-Demand Male Contraceptive Pill
Weill Cornell Medicine researchers have received an $8.2 million NIH grant to advance an experimental on-demand male contraceptive pill, which ...
Ayurvedic phytochemicals offer a multi-target route against antimicrobial resistance
A preclinical review identifies Ayurvedic phytochemicals as possible multi-target antibiotic adjuncts that could disrupt biofilms and resistance machinery, but safety, ...
Nebulized budesonide formulations match with and without charcoal blockade
Two randomized crossover trials found equivalent systemic exposure for test and reference nebulized budesonide in healthy Chinese adults, with and ...
Singapore’s A*STAR and HistoIndex Join Forces to Speed Fibrosis Drug Development
Singapore's A*STAR has signed a Memorandum of Understanding with AI digital pathology firm HistoIndex to quantitatively evaluate preclinical therapeutic candidates ...
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