Trivalent Antiviral Conjugates Trap Influenza Viruses by Cross-Linking Them Together
A programmable multivalent antiviral conjugate platform shows that attaching three copies of a neuraminidase inhibitor to an Fc fragment cross-links ...
Tag: Drug development
Quality by Design: The Blueprint for Faster, Safer Pandemic Drug Development
A new mini review argues that Quality by Design and Analytical Quality by Design could serve as a Pandemic-Ready Development ...
New AI Framework Maps Drug Sensitivity Down to Individual Cells in Bulk Tumor Samples
A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...
Inside the UC Davis Testing Center Putting Lab-Grown Organoids and AI Models to the Real-World Test
The UC Davis NAMs Testing Center offers an independent, fit-for-purpose evaluation model for organoids, microphysiological systems and computational tools as ...
RAGE: The Diabetes Signaling Hub That Could Be Blocked Without Breaking the Brain
A new review positions the AGE–RAGE axis as a self-amplifying inflammatory hub driving diabetic complications, while warning that therapies must ...
Human Brain Tissue Reveals a Cortex Built on Different Rules Than Rodents
A new collection of studies using live human cortical tissue shows that human neurons and circuits follow distinct structural, physiological, ...
AI and the Digital Exhaust: How Everyday Data Could Transform Huntington’s Disease Drug Development
A new review argues that AI-driven passive monitoring of everyday digital data, from smartphone keystrokes to home radar sensors, could ...
Organ-on-Chip Meets Digital Twin: Systematic Review Maps the Future of Drug Development
A new systematic review of 123 studies shows that pairing organ-on-chip devices with digital twin computational models is rapidly maturing ...
Children Are Being Left Behind as Antifungal Resistance Gathers Pace, Global Pediatric Group Warns
A new International Pediatric Association analysis reveals that none of five novel antifungal drugs in late-stage development has pediatric efficacy ...
Drug Penetration Into Lung Cavities Predicts Which Tuberculosis Regimens Can Be Shortened
A validated translational platform linking lesion drug penetration to Phase 3 trial outcomes offers a new way to design shorter ...
Scientists Map a Battle Plan Against One of Medicine’s Rarest and Deadliest Childhood Cancers
An international expert workshop has prioritised targets and trial designs to break the three-decade therapeutic stalemate in desmoplastic small round ...
Trapping rogue DNA rings in micronuclei could disarm aggressive tumors
An international research team has shown that rings of extrachromosomal DNA lose their cancer-driving activity when trapped in micronuclei, a ...
Scientists Receive Up to $51.7 Million to Predict Protein Misfolding Before Disease Begins
A co-led Buck Institute and Georgetown University team has won an ARPA-H award of up to $51.7 million to predict ...
Scientists Identify HERC4 as the Molecular Switch That Turns TNF Survival Signals Into Cell Death
Researchers have discovered that the protein HERC4 acts as the critical molecular switch that converts TNF survival signalling into cell ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
Stem Cell Models to Reveal Why Parkinson’s Disease Hits Women Differently
Critical Path Institute and the University of Arizona have launched a two-year collaboration using human stem cell-derived neurons and new ...
Bridging the Lab and the Clinic: Why Addiction Science Needs Translational Research
A new commentary in the Journal of Translational Medicine argues that refined animal models and emerging tools like rodent fMRI ...
Iron, Inflammation, and a Deadly Paradox: Rethinking Cancer Wasting Through Ferroptosis
A new iScience review argues that ferroptosis, an iron-driven form of cell death, links tumor and immune signals to muscle ...
Gut diseases in miniature: organoids and organ-on-a-chip models reshape gastrointestinal research
A Nature Biomedical Engineering review synthesises how organoids and organ-on-a-chip technologies are transforming the modelling of inflammatory, infectious and neoplastic ...
Human Organs on Chips Recreate Body’s Niches to Predict Drug Safety
A Stanford-led review in Nature Biomedical Engineering maps how multi-organ tissue chips that preserve each organ's native niche could transform ...
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