Dual Susceptibility Gene Knockout Cuts Nematode Multiplication by 56 Percent
Simultaneous knockout of two susceptibility genes reduced root-knot nematode multiplication by over 56 percent without affecting host plant fitness.
Tag: CRISPR-Cas9
Posterior Ring Proteins Anchor Mouse Sperm Head to Tail for Motility
Researchers have identified SPEM3 and TEX50 as essential structural proteins of the sperm posterior ring that anchor the head to ...
CRISPR Gene Deletions Reveal How Plant Tandem Arrays Control Cold Tolerance
Scientists using CRISPR/Cas9 multi-gene deletions in Arabidopsis thaliana have demonstrated that plant freezing tolerance relies on functional redundancy across the ...
SETDB1 and HUSH Complexes Restrict Single-Stranded DNA Incorporation During Genome Editing
Researchers have identified the SETDB1/ATF7IP heterodimer and HUSH complex as major epigenetic barriers that restrict single-stranded DNA incorporation during nickase-mediated ...
Engineered Viral Vector Enables Choroid Plexus Gene Editing Across Rodent Ventricles
A novel engineered adeno-associated virus demonstrates choroid plexus tropism across species and delivers targeted CRISPR gene editing in mice while ...
CRISPR Cleaves Ubiquitous RNA to Halve Intestinal Single-Cell Sequencing Costs
Targeted CRISPR-Cas9 enzymatic depletion removes non-variable transcripts from human intestinal single-cell libraries, maintaining high data fidelity while cutting required sequencing ...
Mouse Model Links Inflammation to SCA13 Neurodegeneration
A new mouse model of spinocerebellar ataxia 13 reveals a strong association between neuroinflammation and Purkinje cell loss, suggesting a ...
Scientists Identify Single Gene Mutation Causing Quorn Fungus Branching Defect
Researchers have identified mutations in the LRG1 ortholog jg4843 as the genetic cause of hyper-branching colonial variants that disrupt commercial ...
Loss of BMP15 Gene Function Does Not Abolish Male Atlantic Salmon Fertility
A targeted CRISPR knockout study reveals that Atlantic salmon lacking functional bmp15 maintain testicular development, normal androgen levels, and viable ...
CRISPR Advances Reshape Ornamental Crop Breeding and Global Floriculture Regulations
A comprehensive scientific review outlines how CRISPR-mediated genome editing overcomes longstanding genetic hurdles in ornamental crops while navigating divergent international ...
Decade of Tomato Brown Rugose Fruit Virus Research Highlights Genetic Resistance Priorities
A bibliometric analysis of 255 scientific documents published between 2016 and 2025 shows that global tomato brown rugose fruit virus ...
Chemical Mutagenesis Uncovers Target of Antileishmanial Aminopyrazole Compounds
Researchers identified the endocytic vesicle protein LINF_180011100 as a molecular target and resistance determinant for antileishmanial aminopyrazoles using chemical mutagenesis.
CRISPR Beta-Cell Regeneration Shows Early Promise for Long-Term Diabetes Management
A scientific review details how CRISPR-Cas9 gene editing is advancing through preclinical models and early clinical trials to regenerate insulin-producing ...
Nanobody Degrade System Targets Proteins in Slime Mold
Researchers developed a nanobody-based degron system called dictyGrad-ALFA that enables efficient, cell type-specific protein knockdown in Dictyostelium discoideum, overcoming limitations ...
CTCF-FADS1 Axis Regulates Oncogenic Energy Metabolism in Liver Cancer
Researchers identified a CTCF-FADS1 regulatory axis that controls energy metabolism and tumor growth in hepatocellular carcinoma cells.
DNAH14 Gene Loss Drives Ependymal Cilia Dysfunction and Hydrocephalus in Mice
A study in mice demonstrates that DNAH14 knockout impairs ependymal ciliary motility, leading to chronic hydrocephalus, behavioral deficits, and hippocampal ...
Review Highlights CRISPR-Modified Mesenchymal Stromal Cells for Bone and Cartilage Repair
A review examines how CRISPR-edited mesenchymal stromal cells could advance bone and cartilage repair while noting that clinical translation remains ...
CRISPR Gene Therapy for Sickle Cell and Thalassemia Shows Strong Efficacy, but Long-Term Safety Questions Remain
A systematic review of 21 studies finds CRISPR/Cas9 therapies for beta-thalassemia and sickle cell disease achieve high transfusion independence and ...
Water Channel Protein AQP4 Emerges as a Driver of Age-Related Muscle Loss
A new rat and cell-line study finds that the water channel protein AQP4 declines in aged muscle and that silencing ...
Prime Editing Moves Toward In Vivo Gene Correction for Genetic Diseases
A new review maps how prime editing, a CRISPR-derived tool capable in principle of correcting 89 percent of human pathogenic ...
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