Androgen receptor loss tracks with aggressive endometrial cancer in small study
A retrospective study of 40 endometrial carcinoma tissue samples found androgen receptor expression in half of the tumors, restricted entirely ...
Tag: biomarker
SLC7A5 emerges as a central player in cancer amino acid metabolism
A new review summarizes how the amino acid transporter SLC7A5 drives tumor metabolic reprogramming and where targeted therapies against it ...
Chemoradiotherapy Lowers Circulating miR-21 Levels in Stage III Lung Cancer Patients
A prospective pilot study of 21 stage III NSCLC patients found that serum extracellular vesicle–enriched miR-21 significantly decreased after chemoradiotherapy, ...
STOML2 Drives Liver Cancer Cell Growth Through PI3K/AKT Pathway Activation
A new study reports that the protein STOML2 is overexpressed in hepatocellular carcinoma and that silencing it in a liver ...
Liver Cancer Protein AKR1B10 Could Aid Childhood Tumor Diagnosis, Review Proposes
A new hypothesis-generating review proposes that the adult liver cancer blood marker AKR1B10 may also hold diagnostic value for pediatric ...
Kidney filter estimates that disagree may flag immune vulnerability in HIV
A retrospective study of 409 treated people with HIV found that a common pattern of disagreement between creatinine- and cystatin ...
Honeybee Heat Shock Gene AccDnaJC28 Emerges as Environmental Stress Biomarker
A new study finds that the honeybee heat shock protein gene AccDnaJC28 is induced by heat, cold, pesticides, and UV ...
Blood PGLYRP1 mRNA shows promise as early marker of ARDS in sepsis
A retrospective cohort study found that peripheral blood leukocyte PGLYRP1 mRNA measured within two hours of ICU admission was associated ...
Mitochondrial Enzyme FDXR Emerges as Prognostic Marker in Leukemia Linked to HTLV-1
Researchers report that the mitochondrial enzyme FDXR is upregulated in HTLV-1-infected cells, tracks disease severity and prognosis in adult T-cell ...
MicroRNA miR-3663-3p emerges as diagnostic marker and driver of kidney disease vascular calcification
A new study finds miR-3663-3p is upregulated in chronic kidney disease patients with vascular calcification and promotes calcification in a ...
Plasma GDF15 Shows Diagnostic Potential in Biopsy-Indicated Prostate Cancer Cohort
A biopsy-indicated cohort study found plasma GDF15 achieved an AUC of 0.805 for prostate cancer detection, and a nomogram combining ...
Gut Microbe Butyrate Signature Flags Early Resistance to Immunotherapy in Lung Cancer
A combined gut microbiome score linking probiotic-associated bacteria and butyrate production capacity was associated with early resistance to anti-PD-1 therapy ...
POSTN+ tumor-associated endothelial cells promote and predict pulmonary metastasis in osteosarcoma
Researchers identified a POSTN-expressing tumor-associated endothelial cell subset that promotes and predicts pulmonary metastasis in osteosarcoma.
Urine biomarker flags kidney transplant rejection before it strikes
A small clinical study found that urinary hsa_circ_0001334 was markedly elevated in kidney transplant recipients who later developed biopsy-proven rejection.
B Cell Depletion Marks High-Risk Hodgkin Lymphoma, Spatial Study Finds
A spatial transcriptomics study links depletion of non-tumoral B cells to relapse risk in classical Hodgkin lymphoma and introduces an ...
Blood enzyme autotaxin tracks lupus activity and flags active kidney disease
A cross-sectional study of 60 lupus patients found serum autotaxin levels rose with disease activity and distinguished active lupus nephritis ...
Sperm Protamine Gene Imbalance Emerges as Molecular Signature of Male Infertility
A case-control study of 279 infertile and 32 fertile men found that the PRM1/PRM2 sperm mRNA transcript ratio was significantly ...
DNA Methylation Score Sharpens Leukemia Risk Prediction in MDS
A 55-CpG DNA methylation signature developed from bone marrow samples and validated in an independent cohort appears to predict AML ...
Stemness-Based Gene Signature Predicts Survival and Treatment Response in Liver Cancer
Researchers built a seven-gene tumor stemness signature from single-cell and bulk transcriptomic data that predicts survival, immunotherapy response, and oxaliplatin ...
Serum microRNA miR-1287-5p emerges as a candidate biomarker and driver of knee osteoarthritis
A single-centre study found serum miR-1287-5p elevated in knee osteoarthritis patients and showed in chondrocyte experiments that the microRNA promotes ...
