Newly identified piRNA linked to congenital heart disease in foetal rats
Researchers identified the piRNA CHDPIR, upregulated in maternal plasma extracellular vesicles and foetal heart tissue in congenital heart disease, and ...
Tag: biomarker
Tumor TNF-α Drives CCL4-Producing Neutrophils Linked to Immunotherapy Resistance in Lung Cancer
A new study links tumor-derived TNF-α, CCL4-high tumor-associated neutrophils, and suppressed T-cell activity to immunotherapy resistance in non-small cell lung ...
Obesity-linked leptin drives DNA hypomethylation in breast epithelial cells
A new study links obesity-associated leptin levels to global DNA hypomethylation and altered EMT gene expression in breast epithelial cells, ...
MR elastography reveals restricted muscle sliding in chronic low back pain
MR elastography-based slip interface imaging showed excellent repeatability and detected reduced sliding between lumbar muscles in chronic low back pain ...
Triglyceride-Glucose-Frailty Index Shows Strong Link to Cardiovascular Risk
A nine-year cohort study finds that a composite index combining triglyceride-glucose levels with frailty measures strongly predicts incident cardiovascular disease ...
Blood Cholesterol Marker Flags Brain Injury Risk in Growth-Restricted Infants
A blood-based cholesterol metabolite, 24S-hydroxycholesterol, shows reduced levels in IUGR infants and predicts neurodevelopmental risk in new mouse and clinical ...
Tear Fluid α-Synuclein Shows Promise as Noninvasive Biomarker for Parkinson’s Disease
A pilot cross-sectional study found significantly elevated total α-synuclein in non-stimulated basal tears of Parkinson's disease patients, with moderate diagnostic ...
Simple Blood Ratio Linked to Short-Term Death Risk After Heart Attack
A study of 4,213 critically ill heart attack patients in the MIMIC-IV database found that a higher hemoglobin-to-red cell distribution ...
CD84 Levels Predict Venetoclax Response in Acute Myeloid Leukemia
High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...
NAT10 and USP19 jointly stabilize CDH3 to drive colorectal cancer growth and immune evasion
A new study reports that NAT10-mediated mRNA acetylation and USP19-mediated deubiquitination jointly stabilize CDH3, promoting colorectal cancer progression and immune ...
Cellular Stress Protein JWA Emerges as Context-Dependent Redox Hub in Aging and Disease
A new narrative review synthesizes how the multifunctional protein JWA intersects with redox homeostasis across cancer, neurodegeneration and tissue injury, ...
New Automated qPCR Assay Shows TTV Viral Loads Fluctuate Naturally Over Time
A newly developed, analytically validated automated qPCR assay for Torque teno virus DNA achieved a limit of detection of 32.3 ...
Immune Gene Variant and Raised IL-27 Levels Linked to Neonatal Cholestasis Risk
A case-control study in Egypt found that the IL-27 rs181206 T allele and TT genotype were strongly associated with neonatal ...
TTC39B emerges as a pan-cancer prognostic marker suppressing renal cancer cell growth
A pan-cancer analysis links TTC39B expression to prognosis and tumor immunity across 33 cancer types, with experiments showing the gene ...
Lactate-to-Albumin Ratio Flags Mortality Risk in Sepsis-Induced Myocardial Injury
A retrospective MIMIC-IV cohort study of 836 adults with sepsis-induced myocardial injury found the highest lactate-to-albumin ratio quartile carried more ...
EGF-depleting vaccine plus nivolumab shows survival signal in advanced NSCLC
A phase II trial reports 11.9-month median overall survival with CIMAvax-EGF plus nivolumab in previously treated advanced NSCLC, with the ...
tRF Fragment Drives AML Cell Growth by Suppressing AGGF1, Study Finds
A tRNA-derived RNA fragment elevated in acute myeloid leukemia promotes cell growth and survival by suppressing AGGF1 and is associated ...
Early TTR Rise on Tafamidis Tied to Lower Death Risk in ATTR-CM Trial Analysis
A post hoc analysis of the ATTR-ACT trial found that early increases in TTR concentration after tafamidis treatment were associated ...
Protein Linked to Re-Blocked Tear Ducts After Keyhole Eye Surgery
Proteomic screening of nasal mucosal tissue from 30 patients identified RBM39 as upregulated in cases of re-obstruction after tear duct ...
Androgen receptor loss tracks with aggressive endometrial cancer in small study
A retrospective study of 40 endometrial carcinoma tissue samples found androgen receptor expression in half of the tumors, restricted entirely ...
