Nanotechnology Strategies Target Drug-Resistant Tuberculosis Infections with Precision Delivery Platforms
Engineered nanomaterials and responsive delivery platforms provide targeted mechanisms to overcome multidrug-resistant tuberculosis infections.
Tag: Antimicrobial peptides
Review Links Lichen Sclerosus to Genital Dysbiosis and Immune Activation Pathways
A comprehensive narrative review shows that microbial imbalances across genital and gut tissues may actively drive chronic inflammation and tissue ...
Algae-Produced Trimeric Peptide Disrupts Bacterial Membranes to Inhibit Pathogen Growth
A recombinant trimeric crustin peptide expressed in the microalga Chlamydomonas reinhardtii disrupts bacterial cell membranes and inhibits both Gram-positive and ...
Machine Learning Model Predicts Antimicrobial Peptide Synergy With High Test Accuracy
Supervised machine learning algorithms successfully predicted synergistic combinations between antimicrobial peptides and conventional antimicrobial agents using fractional inhibitory concentration data.
Genome Sequencing Uncovers Potent Antimicrobial Clusters in Mangrove Bacterium Bacillus velezensis
Whole genome sequencing of mangrove-derived Bacillus velezensis G7 reveals eight antimicrobial biosynthetic gene clusters and broad-spectrum inhibitory activity against bacterial ...
Endangered Edible Species Hold Bioactive Compounds, Systematic Review Finds
A systematic review of 122 studies finds that endangered edible species carry exceptionally rich bioactive profiles, including compounds with reported ...
Soybean Disease Linked to Bacteria Resisting Host Defenses
Single-cell genomics reveals that soybean red crown rot is associated with the enrichment of Enterobacterales bacteria carrying genes for resistance ...
Alignment-Free Deep Learning Framework Discovers Antimicrobial Peptides in Insect Proteomes
Researchers have introduced iAMP-Deep, an alignment-free artificial intelligence framework that combines multimodal sequence embeddings and ensemble learning to discover divergent ...
Phage K Holin’s C-Terminal Region Shapes Antibacterial Activity, Study Finds
Researchers report that the antibacterial activity of the bacteriophage K holin depends on coordinated action between its transmembrane domain and ...
Computer screen sifts animal peptides for breast cancer drug leads
A computational pipeline filtered about 1,500 animal-derived antimicrobial peptides down to three candidates that dock strongly against the breast cancer ...
Engineered Fly-Larva Peptide KK12 Curbs Salmonella on Cooked Chicken in Lab Test
A rationally engineered peptide from black soldier fly larvae showed strong antibacterial activity against Salmonella Typhimurium in laboratory tests and ...
Capsule Networks Push Antimicrobial Peptide Prediction Past 97 Percent Accuracy
A capsule neural network model called AMP-CapsNet achieved 97.29 percent test accuracy in classifying antimicrobial peptides when using dipeptide composition ...
Peptidomics offers aquaculture a new route to sustainable feeds and food security
A new review outlines how peptidomics, the large-scale analysis of peptides, could help aquaculture develop sustainable feeds, reduce antibiotic use ...
Vaccination and Biosecurity Lead the Field in Cutting Livestock Antibiotic Dependence
A critical narrative review finds vaccination and biosecurity are the only livestock alternatives with strong field-scale evidence for reducing antimicrobial ...
Bacterial Biofilms Emerge as Hidden Engine of the Antimicrobial Resistance Crisis
A new review reports that bacteria in biofilms can resist antibiotics up to 1,000 times more than planktonic cells, driving ...
Yeasts Lead the Race to Mass-Produce Next-Generation Antimicrobial Peptides
A new review argues that yeasts, especially Pichia pastoris, are the leading fungal platforms for scalable recombinant production of antimicrobial ...
Computational Design Yields Chimeric LL-37/HNP-1 Peptide Candidate for Respiratory Co-Infections
A new computational study reports the design and in-silico evaluation of a chimeric antimicrobial peptide fusing LL-37 and HNP-1 domains ...
Genomic and functional characterization of the respiratory commensal Haemophilus paraphrohaemolyticus reveals production of anti-streptococcal peptides
A low-abundance nasopharyngeal commensal, Haemophilus paraphrohaemolyticus, produces antimicrobial peptides that selectively target Streptococcus species without harming other airway bacteria or ...
Beyond antibiotics: which antimicrobial alternatives are actually ready for the clinic?
A critical narrative review finds that most non-antibiotic antimicrobial strategies remain preclinical, with only phage therapy, antimicrobial peptides, silver formulations ...
Plants Wage Chemical Warfare Against Pathogens, and Scientists Are Learning to Weaponize It
A comprehensive review maps how plants deploy bioactive compounds against pathogens and outlines genetic, nanotech and microbiome strategies to engineer ...
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