Psychobiotics and Fermented Foods May Target the Gut-Brain Axis in Alzheimer’s Disease
A new review finds that psychobiotics and fermented foods show neuroprotective effects in animal models of Alzheimer's disease, while clinical ...
Tag: amyloid-beta
New study tracks amyloid-beta and blood-brain barrier leakage in CAA
A new protocol study will track longitudinal changes in cerebrospinal fluid amyloid-beta peptides and blood-brain barrier dysfunction in cerebral amyloid ...
Synthetic Receptors Rewired to Sense Amyloid Beta and Release Therapeutics in the Lab
A head-to-head laboratory comparison found that SNIPR and synNotch receptors, but not TRUCKs, supported amyloid beta-dependent expression of therapeutic transgenes ...
Blood–Brain Barrier Breakdown Speeds Alzheimer’s-Like Damage in Fruit Flies
Knocking down the receptor moody in Drosophila barrier glia increased permeability and, together with human amyloid-beta expression, worsened neurodegeneration without ...
Plasma exchange cuts amyloid plaques in aged Alzheimer’s model mice
A mouse study reports that monthly plasma exchange with albumin, started at an advanced stage of amyloid pathology, reduced insoluble ...
Cell Talk at the Blood-Brain Barrier Switches On Insulin Signaling
Co-culturing human brain endothelial cells with pericytes activates AKT and ERK insulin signaling, raises TIMP1 and collagen-IV, inhibits MMP activity ...
CSF APOE4 protein levels track tau pathology better than HDL measures in Alzheimer’s
A study of 144 ADNI participants found that CSF APOE4 protein levels, not HDL particle concentrations, were associated with tau ...
Green Tea and Soy Phytochemicals Show Neuroprotective Effects in Lab Models of Alzheimer’s Disease
A new in vitro study finds that epicatechin gallate from green tea and genistin from soybeans inhibit cholinesterases, reduce oxidative ...
High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup
A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...
Alzheimer’s Mouse Model Shows Sex-Specific Muscle Fatigue Changes Before Cognitive Decline
In a humanized amyloid beta knock-in mouse model of sporadic Alzheimer's disease, 8-month-old males show faster muscle fatigue while females ...
Amyloid biomarkers track sleep spindle changes in cognitively healthy older adults
In cognitively unimpaired adults aged 55 to 75, plasma amyloid-beta levels were consistently associated with shorter and less dense frontal ...
Experimental drug rejuvenates aged rat livers, halving amyloid beta and LDL
In aged rats, the experimental drug cinaciguat restored aging liver sieve cells, cutting blood amyloid beta in half and lowering ...
Alzheimer’s Breakthrough Clue: How the Cell’s Waste Disposal System Breaks the Brain’s Amyloid Pump
A new review argues that the ubiquitin-proteasome system degrades P-glycoprotein at the blood-brain barrier, impairing amyloid-beta clearance and offering new ...
Inside China’s Lecanemab Experiment: What Families Really Think of the New Alzheimer’s Drug
A new qualitative study from West China Hospital reveals how family caregivers of Alzheimer's patients in China experience lecanemab treatment, ...
AI-Designed Enzymes Slice Disease Proteins With Unprecedented Precision
Researchers have used AI-driven protein design to create entirely new zinc-dependent proteases that cleave disease-linked proteins such as TDP-43 and ...
Synapses Under Siege: How Plant Compounds May Rebuild the Brain’s Failing Connections in Alzheimer’s Disease
A new review reveals that synaptic failure—not plaque burden—is the strongest driver of Alzheimer's cognitive decline, and plant-derived phytochemicals may ...
Real-World Data Show Lecanemab Is Mostly Safe but Flag a Stroke Signal
A combined real-world cohort and FAERS analysis finds lecanemab generally safe in Alzheimer's patients but flags a strong, unlabeled signal ...
Scientists Date Alzheimer Plaques in Living Human Brain for the First Time
Researchers have for the first time captured and chemically dated Alzheimer disease pathology in living human brain tissue, revealing rapid ...
Indanone Compounds Show Promise Against Parkinson’s and Alzheimer’s in Animal Studies
Indian researchers have synthesized arylidene indanone derivatives that restore motor function in Parkinson's model mice and memory in Alzheimer's model ...
Could Failing Myelin Flexibility Drive Cognitive Decline in Alzheimer’s Disease?
A new Perspective in PLOS Biology proposes that Alzheimer's disease may impair activity-dependent adaptive myelination by gray-matter oligodendrocytes, contributing to ...
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