Sage Shows Six-Way Brain Protection in New Review of Preclinical and Clinical Evidence
A new review in Molecular Biology Reports synthesizes in vitro, animal, and clinical evidence on six molecular mechanisms by which ...
Tag: amyloid-beta
Amyloid beta disrupts mitochondrial ceramide signals and lysosomal stress in Alzheimer’s models
A study in EMBO Reports reports that mitochondrial APP and Aβ40 are associated with reduced CerS1/C18-ceramide accumulation and mitophagy readouts ...
Two Rare Brain Vessel Inflammations Look Alike but Differ in Biology, Diagnosis, and Outcome
A new review compares cerebral amyloid angiopathy-related inflammation with primary angiitis of the central nervous system, showing they overlap clinically ...
Cigarette smoke cadmium may fuel Alzheimer’s damage through JNK2 brain pathway
A new study links smoking-associated cadmium to JNK2 activation in neurons, driving mitochondrial dysfunction and APP accumulation relevant to Alzheimer's ...
Alzheimer’s Biomarkers Run Lower in African American Participants, Meta-Analysis Finds
A meta-analysis of eighteen studies found that African American participants had significantly lower tau and neurodegeneration biomarker levels in cerebrospinal ...
Acetylcholinesterase emerges as a multifaceted player in Alzheimer’s disease pathogenesis
A new review argues that acetylcholinesterase acts beyond breaking down acetylcholine, accelerating amyloid-beta aggregation and tau pathology while remaining a ...
Astrocytic Cilia Receptor Drives Amyloid Beta Accumulation and Brain Cell Stress
Researchers have discovered that the ciliary p75 neurotrophin receptor mediates amyloid beta accumulation and oxidative stress in human hippocampal astrocytes.
Lipid nanoparticles get a pathway-matched blueprint for Alzheimer’s drug delivery
A new review proposes matching lipid nanoparticle designs to specific Alzheimer's disease pathways, from neuronal BACE1 siRNA delivery to microglia-targeted ...
Circular RNA Protein Aβ175 Characterized In Silico in Alzheimer’s Study
A computational study from the University of Kalyani predicts the structural features of Aβ175, a protein encoded by the circular ...
Light Therapy Clears Brain Waste in Young and Middle-Aged Mice but Fails in Old Ones
A mouse study finds that photobiomodulation improves learning and amyloid beta clearance in young and middle-aged animals, but not in ...
Vagus Nerve Stimulation Curbs Amyloid Buildup After Surgery in Mice With Alzheimer-Like Disease
In Alzheimer-model mice, minimally invasive vagus nerve stimulation delivered right after orthopedic surgery reduced acute amyloid-beta accumulation, neuronal loss and ...
Histone Marks May Hold Alzheimer’s Inflammation in a Persistent State
A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.
Loss of CADM3 worsens amyloid buildup and synaptic damage in Alzheimer’s mice
A new study reports that CADM3 expression drops in human Alzheimer's brains and that its genetic loss worsens amyloid deposition, ...
Review assesses tentative gut microbiota and neuroimmune roles in Alzheimer’s disease
A review integrates associative observations in patients with Alzheimer's disease and mild cognitive impairment alongside experimental and animal findings on ...
Sleep loss after brain injury boosts early Alzheimer-like protein changes in mice
A new mouse study shows that traumatic brain injury alone triggers early Alzheimer-like protein variant buildup in wild-type animals, and ...
![Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer's drug design](https://bioengineer.org/wp-content/uploads/2026/10/stackrss-featured-24177-350x250.png)
Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer’s drug design
A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing ...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's ...
FcRn Blockade Lowers IgG and Alters Amyloid Pathology in Alzheimer’s Model Mice
Blocking the neonatal Fc receptor with efgartigimod reduced circulating IgG and was associated with lower amyloid burden and markers of ...
Beta-brain-wave dips may link amyloid buildup to memory loss in early Alzheimer’s
A resting-state EEG study of amyloid-positive mild cognitive impairment finds that reduced beta-band activity indirectly links amyloid burden to memory ...
Cannabidiol shows preclinical promise against Alzheimer’s disease, but key evidence gaps remain
A new review finds cannabidiol consistently reduces neuroinflammation and oxidative stress in Alzheimer's preclinical models, but evidence for amyloid, tau, ...
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