In recent years, the adolescent and young adult (AYA) cancer survivor population has gained increasing attention within oncological research, particularly due to their unique psychosocial needs that differ markedly from both pediatric and older adult populations. However, much of the foundational research into these challenges has primarily focused on Western cohorts, leaving significant gaps concerning how AYAs with cancer in Asian contexts experience the aftermath of their diagnoses. A groundbreaking scoping review published in BMC Cancer addresses this gap, offering a comprehensive synthesis of evidence about the psychosocial hurdles faced by Asian AYAs with cancer, moving beyond clinical outcomes to unveil a more nuanced social and emotional landscape.
The review meticulously collates data from studies published between 2000 and 2023, emphasizing participants aged 15 to 39 years who were diagnosed with cancer and residing in various Asian countries. This age bracket is critical as it represents a pivotal developmental phase marked by educational attainment, career establishment, burgeoning romantic relationships, and family formation—domains deeply affected by a cancer diagnosis. The authors foreground four thematic areas where psychosocial challenges intertwine with cultural, economic, and healthcare factors: work and school performance, financial distress, interpersonal relationships, and fertility-related concerns.
One striking insight from the review is the complex effects cancer has on AYAs’ educational and vocational trajectories. While three quantitative studies included found no significant difference in resignation or unemployment rates between cancer survivors and non-cancer controls, a substantial proportion—ranging from 21% to 40%—reported specific anxieties about employment stability and impaired work capacity post-diagnosis. These seemingly contradictory findings point to an underlying heterogeneity influenced by the socio-economic context, cancer types, and availability of supportive employment policies, suggesting that quantitative metrics alone may inadequately capture the lived experiences of these young survivors.
Social relationships, particularly involving family, emerge as a crucial vector of psychosocial well-being in Asian AYAs with cancer. The review highlights a pronounced sociocultural difference when juxtaposed with Western populations, where peer relationships often dominate adolescent psychosocial frameworks. In Asian settings, filial piety, extended family networks, and collectivist cultural values underpin the predominance of family dynamics in survivors’ emotional experiences. Studies noted disruptions in family roles and communication patterns following diagnosis, often compounded by health-related anxieties and economic burdens that shifted familial responsibilities unexpectedly onto young survivors.
Romantic relationships were also examined, albeit to a lesser extent within the reviewed literature. Cancer-induced health changes and body image concerns, coupled with cultural stigmas regarding illness and fertility, created barriers for AYAs seeking or maintaining intimate partnerships. This psychosocial domain remains under-explored in Asian contexts, suggesting a critical area for future research and intervention development tailored to regional cultural norms and expectations.
Financial distress looms large as a pervasive challenge, intricately linked to the broader healthcare infrastructure and socioeconomic stratification across Asia. The variability among countries in access to affordable cancer care, insurance coverage, and social safety nets means that AYAs face vastly different realities in managing treatment costs and associated expenses. The review calls attention to the pressing need for region-specific policies to mitigate financial toxicity, which critically impacts not only treatment adherence but also long-term psychosocial outcomes and quality of life.
Perhaps one of the most stark gaps identified is in addressing fertility preservation—a domain of profound concern for many AYAs facing cancer treatments known for their gonadotoxic effects. The review underscores a consistent theme of uncertainty and lack of accessible information among patients regarding fertility-related options. Across different studies, survivors reported facing distress stemming from ambiguous counseling, limited availability of fertility preservation services, and cultural taboos that complicated discussions about reproductive health. This deficit compounds the psychosocial burden at a life stage where procreation and parenthood remain core aspirations.
Methodologically, the review adhered to rigorous standards as stipulated by the Joanna Briggs Institute, encompassing both qualitative and quantitative studies. This balanced approach allowed for an integrative understanding that transcends numerical prevalence rates to encapsulate personal narratives and contextual factors critical for meaningful interpretation. Nonetheless, methodological heterogeneity among included studies and the relatively small sample sizes for some outcomes underscore the need for more robust, multi-centered research initiatives across Asia.
The importance of culturally sensitive psychosocial interventions tailored to Asian AYAs emerges as a key implication of the review. Differences in social support structures, stigma, and health literacy necessitate that healthcare providers adapt strategies to local norms while considering the developmental stage and individual variation among AYAs. Family-centered care models, integration of mental health services into oncology settings, and enhanced fertility counseling are prospective pillars for improving survivorship care quality.
The review also illuminates how economic development disparities among Asian nations influence survivorship trajectories. Countries with more advanced healthcare infrastructures show better integration of survivorship programs, though gaps remain. Conversely, resource-limited settings struggle to prioritize survivorship needs amid competing health demands, further emphasizing the importance of targeted policy advocacy and resource allocation.
In synthesizing this diverse body of knowledge, the authors advocate for a paradigm shift in AYA cancer survivorship research and care in Asia—one that moves beyond universal models to embrace distinct cultural, economic, and healthcare realities. The call for comprehensive, region-specific frameworks is anchored in the recognition that survivorship challenges cannot be effectively addressed by imported solutions but require locally generated evidence and stakeholder engagement.
Furthermore, this review contributes to a growing discourse on health equity and the social determinants of health in oncology. By foregrounding psychosocial challenges in an underrepresented population, it aligns with global efforts to reduce disparities and improve holistic care approaches that encompass mental health, socio-economic stability, and reproductive concerns alongside traditional clinical outcomes.
The profound psychosocial implications elucidated here have direct clinical relevance. Healthcare professionals treating Asian AYAs with cancer are encouraged to assess work and school-related functional outcomes, probe financial toxicity, and hold open dialogues about relationships and fertility in culturally appropriate manners. Such comprehensive assessments enable individualized care plans that better support patients’ reintegration into their communities and enhance their overall well-being.
In conclusion, this scoping review represents a seminal contribution to understanding how cultural context shapes the psychosocial landscape for Asian adolescents and young adults with cancer. By highlighting both commonalities and disparities within the region, it provides a roadmap for researchers, clinicians, and policymakers seeking to improve survivorship outcomes through tailored interventions and policies. As cancer survivorship increasingly becomes a global health priority, integrating diverse population perspectives will be key to developing inclusive, effective, and compassionate care for AYAs navigating the complexities of survivorship.
Subject of Research: Psychosocial challenges experienced by adolescent and young adult cancer survivors in Asia.
Article Title: Psychosocial challenges among Asian adolescents and young adults with cancer: a scoping review.
Article References: Wei, Y., Xiao, P., Deng, W. et al. Psychosocial challenges among Asian adolescents and young adults with cancer: a scoping review. BMC Cancer 25, 770 (2025). https://doi.org/10.1186/s12885-025-14169-x
Image Credits: Scienmag.com
DOI: https://doi.org/10.1186/s12885-025-14169-x
Tags: adolescent and young adult cancer survivorscultural factors in cancer careemotional health of young cancer patientsevidence synthesis in cancer researchfertility concerns for young cancer survivorsfinancial distress in cancer patientshealthcare access for Asian AYAsimpact of cancer on education and careerinterpersonal relationships and cancerpsychosocial challenges in Asian youth cancerpsychosocial needs of AYA cancer survivorsscoping review on cancer survivorship