Pancreatic cancer death rates rising across Europe, report reveals
(Vienna, November 15, 2018) Pancreatic cancer death rates in the European Union (EU) have increased by 5% between 1990 and 2016, a report launched today reveals. This is the highest increase in any of the EU's top five cancer killers which, as well as pancreatic cancer, includes lung, colorectal, breast and prostate cancer.
'Pancreatic Cancer Across Europe', published by United European Gastroenterology (UEG) to coincide with World Pancreatic Cancer Day, examines the past and current state of pancreatic cancer care and treatment, as well as the future prospects, such as targeting the microbiome, for improving the prognosis for patients. Whilst lung, breast and colorectal cancer have seen significant reductions in death rates since 1990, deaths from pancreatic cancer continue to rise. Experts also believe that pancreatic cancer has now overtaken breast cancer as the third leading cause of death from cancer in the EU.
Pancreatic cancer has the lowest survival of all cancers in Europe. Responsible for over 95,000 EU deaths every year, the median survival time at the point of diagnosis is just 4.6 months, with patients losing 98% of their healthy life expectancy5. Often referred to as 'the silent killer', symptoms can be hard to identify, thus making it difficult to diagnose the disease early which is essential for life-saving surgery.
Despite the rise in death rates and dreadfully low survival rates, pancreatic cancer receives less than 2% of all cancer research funding in Europe. Markus Peck, UEG expert, explains, "If we are to take a stand against the continent's deadliest cancer, we must address the insufficient research funding; that is where the European Union can lead the way. Whilst medical and scientific innovations have positively changed the prospects for many cancer patients, those diagnosed with pancreatic cancer have not been blessed with much clinically meaningful progress. To deliver earlier diagnoses and improved treatments we need to engage now in more basic as well as applied research to see real progress for our patients in the years to come."
Microbiome – the key to turning the tide?
After forty years of limited progress in pancreatic cancer research, experts claim that new treatment options could finally be on the horizon as researchers investigate how changing the pancreas' microbiome may help to slow tumour growth and enable the body to develop its own 'defence mechanism'. The microbial population of a cancerous pancreas has been found to be approximately 1,000 times larger than that of a non-cancerous pancreas and research has shown that removing bacteria from the gut and pancreas slowed cancer growth and 'reprogrammed' immune cells to react against cancer cells.
This development could lead to significant changes in clinical practice as removing bacterial species could improve the efficacy of chemotherapy or immunotherapy, offering hope that clinicians will finally be able to slow tumour growth, alter metastatic behaviour and ultimately change the disease's progression.
Professor Thomas Seufferlein, pancreatic cancer expert, comments, "Research looking at the impact of the microbiome on pancreatic cancer is a particularly exciting new area, as the pancreas was previously thought of as a sterile organ. Such research will also improve our understanding of the microenvironment in a metastatic setting and how the tumour responds to its environment. This will inform the metastatic behaviour and ultimately alter disease progression."
"With continued investment in pancreatic cancer research, we should have new, important findings within the next five years and, hopefully, find that targeting the microbiome as well as tumour cells will significantly improve treatment outcomes and reduce death rates", adds Professor Seufferlein.
View the report: https://www.ueg.eu/publications/pancreatic-cancer-across-europe/
1. Pancreatic Cancer Across Europe: Taking a united stand (2018). Published by United European Gastroenterology.
2. Ferlay J., Partensky C., Bray F. More deaths from pancreatic cancer than breast cancer in the EU by 2017. ACTA Oncologica, August 2016.
3. Our World In Data, Cancer death rates by type (per 100,000), world. Available at: https://ourworldindata.org/cancer
4. European Cancer Information System (ECIS), Estimates of cancer incidence and mortality in 2018, for all cancer sites. Available at: https://ecis.jrc.ec.europa.eu/explorer.php?$0-0$1-AE28$2-All$4-1,2$3-All$6-0,14$5-2008,2008$7-8$CEstByCancer$X0_8-3$CEstRelativeCanc$X1_8-3$X1_9-AE28
5. Pancreatic Cancer Europe, 10 things you need to know about pancreatic cancer. Available at: https://www.pancreaticcancereurope.eu/work-streams/awareness-and-diagnosis/
Notes to Editors
For further information, or to arrange an expert interview, please contact Luke Paskins on +44 (0)1444 811099 or [email protected]
About Professor Markus Peck
Professor Markus Peck is the Chairman at the Department of Internal Medicine and Gastroenterology (IMuG) at Klinikum Klagenfurt am Wörthersee in Klagenfurt, Austria. He is the Chair of the UEG Public Affairs Committee.
About Professor Thomas Seufferlein
Thomas Seufferlein is a pancreatic cancer expert from the University of Ulm, Germany. He is a member of the UEG Public Affairs Committee.
UEG, or United European Gastroenterology, is a professional non-profit organisation combining all the leading European medical specialist and national societies focusing on digestive health. Together, its member societies represent over 30,000 specialists, working across medicine, surgery, paediatrics, gastrointestinal oncology and endoscopy. This makes UEG the most comprehensive organisation of its kind in the world, and a unique platform for collaboration and the exchange of knowledge. To advance the standards of gastroenterological care and knowledge across the world and to reduce the burden of digestive diseases, UEG offers numerous activities and initiatives, including:
- UEG Week, the biggest congress of its kind in Europe, and one of the two largest in the world
- UEG Education, the universal source of knowledge in gastroenterology, providing online and classroom courses, a huge online library and delivering the latest GI news, fostering debate and discussion
- Activity Grants, promoting and funding educational projects in the field of digestive health to advance and harmonise the training and continuing education of professionals
- UEG Journal, covering translational and clinical studies from all areas of gastroenterology
- Public Affairs, promoting research, prevention, early diagnosis and treatment of digestive diseases, and helping develop an effective health policy for Europe
- Quality of Care, European-based and English clinical practice guidelines, clinical standards, consensus, position papers and standard protocols in the field of digestive health, are available in the repository.
Find out more about UEG's work by visiting http://www.ueg.eu or contact:
Luke Paskins on +44 (0)1444 811099 or [email protected]