• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Sunday, June 15, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Bioengineering

Mutations prevent programmed cell death

Bioengineer by Bioengineer
December 18, 2014
in Bioengineering, Cancer
Reading Time: 2 mins read
2
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Programmed cell death is a mechanism that causes defective and potentially harmful cells to destroy themselves. It serves a number of purposes in the body, including the prevention of malignant tumor growth. Now, researchers at Technische Universität München (TUM) have discovered a previously unknown mechanism for regulating programmed cell death. They have also shown that patients with lymphoma often carry mutations in this signal pathway.

Mutations prevent programmed cell death

Fluorescence microscopy image showing the ubiquitin ligase FBXO25 (green) and the “life-preserving” protein (red) in a cancer cell that is currently undergoing programmed cell death. The yellow signal indicates instances where both proteins are at the same location. (Picture: F. Bassermann / TUM)

A team of scientists headed by Dr. Florian Bassermann at the III. Medizinische Klinik, TUM Klinikum rechts der Isar, has been investigating mantle cell lymphoma, a subgroup of non-Hodgkin’s lymphoma, which, despite new therapies, has poor patient survival rates. “Programmed cell death no longer functions in many lymphoma cells. This causes them to multiply uncontrollably. We urgently need to find out what’s going wrong in these cells in order to find new treatment therapies,” explains Bassermann.

The scientists started analyzing samples of human mantle cell lymphoma in a bid to find errors in the DNA. They discovered a region that is mutated in almost 30 percent of patients. The scientists found that this region plays a key role in producing one particular enzyme, the ubiquitin ligase FBXO25. “We already knew that ubiquitin ligases are involved in breaking down proteins in cells. Now, however, we can show just how it contributes to the development of lymphoma,” explains Bassermann.

Survival strategy of cancer cells

During the course of numerous experiments, the scientists were able to decode a new signal path that triggers programmed cell death. Before a cell can start destroying itself, one particular protein that keeps healthy cells alive has to be removed. The researchers discovered that the ubiquitin ligase FBXO25 marks this protein with a signal molecule which triggers the disposal process.

“If there is a defect in the ubiquitin ligase, this mechanism no longer functions. The tumor cells in question do not destroy themselves and start growing unchecked,” continues Bassermann. The scientists also showed that cells with mutated FBXO25 displayed a much poorer response to chemotherapies, leaving the tumors in a much more stable condition. In a further finding, the researchers discovered other mutations in the cancer cells under investigation. In some cases, the very protein that keeps the cell alive was defective, carrying a mutation that made it resistant to destruction.

New therapies targeting ubiquitin ligase

Once this new signal path had been discovered, the scientists started working on a new therapy approach. They treated the cancer cells in such a way that they were able – once again – to create a functioning variant of the ubiquitin ligase. Instead of multiplying uncontrollably, the cells began destroying themselves again.

“We need to zero in on the exact defect in a tumor cell in order to adapt therapies more closely to individual types of tumors – this is particularly relevant to the field of personalized medicine. Our findings show that this signal path for mantle cell lymphoma could offer a promising approach for new therapies,” concludes Bassermann.

Story Source:

The above story is based on materials provided by Technischen Universität München.

Share12Tweet8Share2ShareShareShare2

Related Posts

Cancer

HPV Identified as Key Driver in Tumor Formation of Rare Nasal Cancers

June 11, 2025
Duan Family Building at Mayo Clinic in Florida

Mayo Clinic Advances Availability of Heavy Particle Therapy for Aggressive Cancers in the Western Hemisphere

June 11, 2025

New Program Empowers Cancer Survivors to Reenter the Workforce with Confidence

June 11, 2025

Study Reveals How American College of Surgeons Accreditation Enhances Quality Improvement

June 11, 2025
Please login to join discussion

POPULAR NEWS

  • Green brake lights in the front could reduce accidents

    Study from TU Graz Reveals Front Brake Lights Could Drastically Diminish Road Accident Rates

    158 shares
    Share 63 Tweet 40
  • New Study Uncovers Unexpected Side Effects of High-Dose Radiation Therapy

    75 shares
    Share 30 Tweet 19
  • Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    69 shares
    Share 28 Tweet 17
  • How Scientists Unraveled the Mystery Behind the Gigantic Size of Extinct Ground Sloths—and What Led to Their Demise

    65 shares
    Share 26 Tweet 16

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

MOVEO Project Launched in Málaga to Revolutionize Mobility Solutions Across Europe

Nerve Fiber Changes in Parkinson’s and Atypical Parkinsonism

Magnetic Soft Millirobot Enables Simultaneous Locomotion, Sensing

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.