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Home NEWS Science News Chemistry

Human contact plays big role in spread of some hospital infections, but not others

Bioengineer by Bioengineer
May 30, 2019
in Chemistry
Reading Time: 3 mins read
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Findings suggest hand hygiene is key, but more methods needed to fight multidrug-resistant infection

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Credit: David Dorward; Ph.D.; National Institute of Allergy and Infectious Diseases.

An observational study conducted in a French hospital showed that human contact was responsible for 90 percent of the spread of one species of antibiotic-resistant bacteria to new patients, but less than 60 percent of the spread of a different species. Audrey Duval of the Versailles Saint Quentin University and Institut Pasteur in Paris, France, and colleagues present these findings in PLOS Computational Biology.

People treated in hospitals and other health care settings are increasingly at risk of infection with multidrug-resistant bacteria. Many of these microbes produce enzymes called extended-spectrum β-lactamases (ESBLs), which make them resistant to antibiotics. Understanding how ESBL bacteria spread from person to person is key to developing effective prevention strategies.

In the new study, Duval and colleagues distributed wearable sensors to hundreds of patients and health care workers in a French hospital. Equipped with RFID tags, the sensors allowed the researchers to track patterns of human contact between patients over an eight-week period. Meanwhile, they systematically screened patients for ESBL-producing Escherichia coli and Klebsiella pneumonia.

The scientists found that 90 percent of the spread of ESBL K. pneumonia to new patients could be explained by direct or indirect contact with patients who had the same bacteria within the previous eight weeks; this figure was less than 60 percent for ESBL E. Coli. The findings suggest that contact-prevention strategies–primarily hand hygiene–can be very efficient in limiting transmission of ESBL K. pneumonia. However, additional measures, such as environmental decontamination or using antibiotics more appropriately, may be necessary to prevent spread of ESBL E. Coli.

The researchers suggest that the same kind of wearable-sensor analysis could be extended to other multidrug-resistant species. Investigation of more detailed genomic data could further illuminate how ESBL-producing bacteria spread.

“By combining digital epidemiology and rapid microbiological diagnostic tools, we may be entering a new era to understand and control the risk of hospital-acquired infection with multidrug-resistant bacteria,” Duval says.

###

Peer-reviewed / Observational study / People

In your coverage please use this URL to provide access to the freely available article in PLOS Computational Biology:
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006496

Citation: Duval A, Obadia T, Boëlle P-Y, Fleury E, Herrmann J-L, Guillemot D, et al. (2019) Close proximity interactions support transmission of ESBL-K. pneumoniae but not ESBL-E. coli in healthcare settings. PLoS Comput Biol 15(5): e1006496. https://doi.org/10.1371/journal.pcbi.1006496

Funding: This study was supported by the European Commission under the Life Science Health Priority of the 6th Framework Program (MOSAR network contract LSHP-CT-2007-037941), funding was also received from the French Government through the National Clinical Research Program and the Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (grant no. ANR-10-LABX-62-IBEID, http://www.agencenationale-recherche.fr/ProjetIA-10-LABX-0062) to DG and from the Ecole des Hautes Etudes en Santé Publique (EHESP, https://www.ehesp.fr/) to AD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.

Media Contact
Didier Guillemot
[email protected]

Related Journal Article

http://dx.doi.org/10.1371/journal.pcbi.1006496

Tags: BacteriologyBiochemistryBiologyBiotechnologyEpidemiologyHealth Care Systems/ServicesInfectious/Emerging DiseasesMedicine/HealthMicrobiologyTechnology/Engineering/Computer Science
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