Cancer
Nepal retrospective study characterizes 51 ALK- or ROS1-positive tumors
A Nepal single-centre retrospective study characterized 51 ALK- or ROS1-positive cases, including 49 non-small cell lung cancers and two inflammatory...
Small single-center study describes dinutuximab beta maintenance for high-risk neuroblastoma
A retrospective study of 13 children at one Chinese center reported 3-year maintenance-phase event-free survival of 69.2% and described adverse...
Early tumor shrinkage associated with longer progression-free survival in measurable advanced gastric or gastroesophageal junction cancer
A retrospective single-center study found that at least 20% early tumor shrinkage was associated with longer progression-free survival after first-line...
MAPK1 variant linked to cervical disease in 300-person study; simulations predict stronger SCH772984 binding to mutant
A 300-person association study linked MAPK1 rs1057519911 to cervical disease, while molecular simulations predicted stronger SCH772984 binding to the E322K...
CCL21-ICAM1 synthetic niche accelerates lytic hit delivery by OT-I T cells against B16 melanoma in vitro
In a two-dimensional mouse-cell study, CCL21-ICAM1 conditioning was associated with an approximately fourfold increase in the model-estimated lytic hit-delivery rate...
CT co-registration yields more stable D90 verification in 30-patient retrospective lung cancer study
A retrospective study in 30 lung cancer patients found that CT co-registration produced postoperative D90 estimates more consistent with the...
Randomized phase III trial with a factorial design assessing the efficacy and safety of darolutamide and stereotactic dose-escalated radiotherapy in patients with high-risk localized prostate cancer: the PEACE 7 (GETUG-AFU 45) study protocol
The PEACE 7 protocol plans a 700-patient phase III trial testing darolutamide and a prostate stereotactic radiotherapy boost in men...
METTL14 stabilizes FDX1 RNA and restrains clear cell kidney cancer
Preclinical experiments show that METTL14 stabilizes FDX1 RNA through m6A methylation, promoting cuproptosis and suppressing clear cell renal cell carcinoma...
Ethiopian case-control study yields internally validated lung cancer risk model
An Ethiopian case-control study developed and internally validated a lung cancer risk model with an AUC of 0.775, while external...
PD-L1-targeted nanosystem shows antitumor activity in triple-negative breast cancer cell and mouse models
A cell and mouse study found that a PD-L1-targeted silver, doxorubicin and manganese dioxide nanosystem increased particle uptake and produced...
Meta-analysis links ARPI-containing prostate cancer therapies with higher reported fracture adverse-event risk
A meta-analysis of 22 phase III randomized trials found that ARPI-containing prostate cancer treatments were associated with higher reported risks...
Four plasma proteins associated with mortality in UK Biobank prostate cancer cohort
A UK Biobank analysis associated GDF15, TNC, TNFRSF10B and RRM2 with all-cause mortality among 353 men with prostate cancer, but...
Longitudinal cohort links chemotherapy cycles with shifting liver, kidney and electrolyte markers in 60 Kenyan cervical cancer patients
A longitudinal cohort study of 60 patients at a Western Kenyan referral hospital found earlier changes in kidney-function markers and...
Murine cervical cancer cell study links KNG1–S1P axis to reprogrammed myeloid-derived suppressor cells
A multi-omics study in murine cervical cancer models found that tumor-conditioned MDSCs underwent sphingolipid metabolic changes centered on a KNG1–sphingosine...
Genome-wide analysis links tumor deletion patterns to alternative DNA repair
A whole-genome analysis of 2,157 tumors across 17 cancer types identified distinct deletion patterns associated with two backup DNA-repair pathways,...
Single-center retrospective study links subcutaneous trastuzumab to higher complete-response odds in HER2-positive breast cancer
A retrospective cohort of 450 East Asian patients with HER2-positive breast cancer found that subcutaneous neoadjuvant trastuzumab was associated with...
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models,...
Real-world cohort links frontline bevacizumab to longer survival in advanced ovarian cancer
A retrospective single-center cohort of 128 patients associated frontline bevacizumab with longer overall survival in advanced ovarian cancer, while clear...
Eight-gene ENE-related RNA signature stratifies metastasis risk and immune features in nasopharyngeal carcinoma
An RNA sequencing study of 159 nasopharyngeal carcinoma patients found that an eight-gene ENE-related signature predicted distant metastasis risk and...
Retrospective two-center study associates postoperative radiotherapy with improved survival in 33 high-risk patients with neuroendocrine cervical carcinoma
A retrospective analysis of 199 patients at two Chinese institutions found that postoperative radiotherapy was associated with higher five-year survival...
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