• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, July 8, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Aging | Parsing chronological and biological age effects on vaccine responses

Bioengineer by Bioengineer
March 27, 2023
in Chemistry
Reading Time: 4 mins read
0
ADVERTISEMENT
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

“Ultimately, while both chronological and biological age appear to be important determinants of vaccine-preventable outcomes in older adults, the underlying context and mechanisms of their effects remain unclear.”

Aging (Aging-US)

Credit: 2023 Verschoor and Kuchel

“Ultimately, while both chronological and biological age appear to be important determinants of vaccine-preventable outcomes in older adults, the underlying context and mechanisms of their effects remain unclear.”

BUFFALO, NY- March 27, 2023 – A new editorial paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 15, Issue 5, entitled, “Parsing chronological and biological age effects on vaccine responses.”

Researchers Chris P. Verschoor and George A. Kuchel from Health Sciences North Research Institute in Ontario, Canada, began this editorial by writing that the COVID-19 pandemic illustrated that older age, particularly when accompanied by common chronic illnesses of aging, is arguably the most significant population attributable factor for severe outcomes of acute respiratory infection, including the risk of hospitalization, disability and death.

“In the absence of widely available and highly effective treatments, vaccines remain our most powerful tool to help overcome this vulnerability through the prevention of primary infection, and far more importantly, by improving clinical outcomes once infection does take place.”

In the case of SARS-CoV-2, vaccine effectiveness (VE) against hospitalization was remarkable for dominant strains prior to omicron, whereas for influenza or Streptococcus pneumoniae VE ranges from 80% to <10%, depending on the season and infecting strain/serotype. Nonetheless, for all three pathogens VE decreases with age, which is caused by deficiencies in the capacity of older adults’ immune systems to mount productive and persistent antibody and/or cell-mediated responses to the vaccine. Given that extremely large, costly and typically lengthy clinical trials are often required to estimate VE reliably, the vast majority of human vaccine studies assess immune correlates of protection as a proxy to VE. For these studies, antibody related parameters such as neutralization capacity are most commonly employed since they are generally simpler from a technical standpoint and many have been rigorously standardized.

“Although informative, cross-sectional studies comparing immune parameters across age groups to understand ‘immune aging’ risk ignore the degree to which departures from healthy aging might contribute.”

 

Continue Reading the Full Editorial: DOI: https://doi.org/10.18632/aging.204572 

Corresponding Author: Chris P. Verschoor

Corresponding Email: [email protected] 

Keywords: biological age, frailty, vaccination, influenza

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204572

 

About Aging-US:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

  • SoundCloud
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LabTube
  • LinkedIn
  • Reddit
  • Pinterest

 

Click here to subscribe to Aging publication updates.

For media inquiries, please contact [email protected].

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###



Journal

Aging-US

DOI

10.18632/aging.204572

Method of Research

Commentary/editorial

Subject of Research

People

Article Title

Parsing chronological and biological age effects on vaccine responses

Article Publication Date

1-Mar-2023

Share12Tweet8Share2ShareShareShare2

Related Posts

Architecture of VBayesMM

Unraveling Gut Bacteria Mysteries Through AI

July 4, 2025
Visulaization of ATLAS collision

Can the Large Hadron Collider Prove String Theory Right?

July 3, 2025

Breakthrough in Gene Therapy: Synthetic DNA Nanoparticles Pave the Way

July 3, 2025

Real-Time Electrochemical Microfluidic Monitoring of Additive Levels in Acidic Copper Plating Solutions for Metal Interconnections

July 3, 2025

POPULAR NEWS

  • Zheng-Rong Lu

    Pancreatic Cancer Vaccines Eradicate Disease in Preclinical Studies

    75 shares
    Share 30 Tweet 19
  • Enhancing Broiler Growth: Mannanase Boosts Performance with Reduced Soy and Energy

    72 shares
    Share 29 Tweet 18
  • AI Achieves Breakthrough in Drug Discovery by Tackling the True Complexity of Aging

    69 shares
    Share 28 Tweet 17
  • New Organic Photoredox Catalysis System Boosts Efficiency, Drawing Inspiration from Photosynthesis

    54 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Microbiome Cell-Free RNA Differentiates Colorectal Cancer

Evolving Deaminase Hotspots for Precise Cytosine Editing

HIV-1 Nuclear Entry Hinges on Capsid and Pore

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.