• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Saturday, September 30, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

UCI researchers reveal critical role of mechanosensor in skin wound healing

Bioengineer by Bioengineer
November 9, 2021
in Biology
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Irvine, CA – November 9, 2021 – PIEZO1, an ion channel mechanosensor found within cells, has been revealed to play a key role in regulating the speed of skin wound healing by researchers at the University of California, Irvine (UCI).

PIEZO1 in wound healing

Credit: UCI School of Medicine

Irvine, CA – November 9, 2021 – PIEZO1, an ion channel mechanosensor found within cells, has been revealed to play a key role in regulating the speed of skin wound healing by researchers at the University of California, Irvine (UCI).

Published today in eLife, the study, titled, “Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing,” found that in mice lacking the ion channel protein PIEZO1 in keratinocytes, skin wounds heal faster than in mice with increased PIEZO1 function in keratinocytes.

“Our collaborators from Ardem Patapoutian’s lab at The Scripps Research Institute, observed that in mice with reduced PIEZO1, wound healing is faster. We wanted to determine the ‘how’, ‘when’ and ‘where’ of PIEZO1’s involvement, in order to find potential treatments that might speed healing,” said Medha Pathak, PhD, assistant professor at the UCI School of Medicine Department of Physiology & Biophysics. “For this, my lab developed new approaches to visualize PIEZO1 while wound healing is taking place in vitro.”

PIEZO1 is among a number of other proteins that are able to sense mechanical cues and provide instructions on the actions the cell should take. Previous research suggested that mechanosensors are instrumental in wound closure, however the specific mechanosensor involved, was unknown.  This was the first study in which the role of PIEZO1 in wound healing was investigated.

The skin, the largest organ of the body, protects against external insults while also enabling touch sensation. Wounding of the skin interferes with these functions and exposes the body to an increased risk of infection, disease and scar formation. During wound healing, keratinocytes, the most abundant cell type in the topmost layer of the skin, move inward from the edges of the wound to close the wound gap. This helps to restore the skin barrier, reestablishing the skin’s protective function.

“Earlier studies in the field showed that mechanical cues regulate keratinocyte migration during wound healing.  Here, we show that in keratinocytes, PIEZO1 is, in fact, acting as the mechanosensor that processes such cues to regulate the speed of wound healing. To our surprise, we found that PIEZO1 accumulates at the wound edge and inhibits healing,” said first author, Jesse Holt, a graduate student in the Pathak Lab. 

The findings from this study provide an understanding of how skin wound healing occurs and have the potential to guide research into new wound healing treatments. However, more research needs to be performed to confirm that reducing the activity of PIEZO1 does not cause unwanted effects, such as reduced touch sensation, and human testing will be required.

PIEZO1 has been identified as a key ion channel with various important physiological roles.  Co-author on this study and the 2021 Nobel Prize laureate Ardem Patapoutian, PhD, a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research, is well known for his work in characterizing the PIEZO1, PIEZO2 and TRPM8 ion channels. PIEZO1 is emerging as an area of active research at UCI: Michael Cahalan, PhD, chair of the UCI School of Medicine Department of Physiology & Biophysics, and Wendy Liu, professor of biomedical engineering also study PIEZO1, in the immune system. In May 2021, the Liu, Cahalan and Pathak labs together reported on the role of the protein in macrophages and the foreign body response; and in July 2021, the Cahalan and Pathak labs published a study identifying PIEZO1 as having an important role in T cell function related to autoimmune neuroinflammatory disorders.

###

This study was funded in part by the National Institutes of Health, Howard Hughes Medical Institute, George Hewitt Foundation for Medical Research, National Science Foundation and the Simons Foundation.

About the UCI School of Medicine

Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and master’s students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and master’s degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/master’s in public health, or an MD/master’s degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.



Journal

eLife

DOI

10.7554/eLife.65415

Method of Research

Experimental study

Subject of Research

Animals

Article Title

Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

Article Publication Date

9-Nov-2021

COI Statement

The authors declare that no competing interests exist.

Share12Tweet8Share2ShareShareShare2

Related Posts

Lifestyle and brain reconstructions of the hypothetical ancestor of modern snakes.

Insights into early snake evolution through brain analysis

September 29, 2023
Aiptasia 1

Did animal evolution begin with a predatory lifestyle?

September 29, 2023

Order from a border

September 29, 2023

Why are killer whales harassing and killing porpoises without eating them?

September 28, 2023

POPULAR NEWS

  • blank

    Microbe Computers

    59 shares
    Share 24 Tweet 15
  • A pioneering study from Politecnico di Milano sheds light on one of the still poorly understood aspects of cancer

    35 shares
    Share 14 Tweet 9
  • Fossil spines reveal deep sea’s past

    34 shares
    Share 14 Tweet 9
  • Scientists go ‘back to the future,’ create flies with ancient genes to study evolution

    75 shares
    Share 30 Tweet 19

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Hairy polymer balls help get genetic blueprints inside T-cells for blood cancer therapy

New study will examine irritable bowel syndrome as long COVID symptom

True progression or pseudoprogression in glioblastoma patients?

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 56 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In