• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, January 21, 2021
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Targeting the PI3K/AKT/mTOR pathway in prostate cancer development and progression

Bioengineer by Bioengineer
June 10, 2016
in Cancer
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

The research article – Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer Development and Progression: Insight to Therapy, by Dr Claudio Festuccia (University of L’Aquila, Italy) and published in Clinical Cancer Drugs, volume 3, issue 1 – discusses experimental and clinical data on the pharmacological inhibition of the Akt/mTOR pathways. These pathways play a key role in the modulation of cellular proliferation, tumor growth and survival through phosphorylation of different downstream molecules. Prostate tumor growth and progression is negatively regulated by Phosphatase and tensin homolog (PTEN) which is genetically and/or functionally silenced in this neoplasia. The aim of the presentation was to analyze the synthesis and functional characterization of different compounds inhibiting phospatidylinositol-4,5-bisphosphate-3-kinase (PI3K), Akt and mTOR activities as well as the feasibility of these inhibitors functioning alone or in combination with standard therapies in aggressive castration resistant prostate cancers (CRPC), a disease stage characterized from high percentage of patients with bone metastases. Conventional treatment for this disease stage requires, indeed, a multidisciplinary approach (medical therapy, surgery, and radiation), but is primarily palliative. Pharmacological resistance is commonly observed. Activation of PI3K/Akt/mTOR pathways plays a significant role in therapy. The blockade of this pathway may be necessary to increase standard therapies. “Several preclinical data support the rationale to advance the use of pharmacological inhibitors of PI3k/Akt/mTOR into clinical trials in CRPC as performed for several other solid tumors” remarked Dr. Festuccia.

###

Author(s): Festuccia Claudio.

Affiliation: Department of Clinical and Applied Sciences and Biotechnologies, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, Italy

This article is open access and can be downloaded from Bentham Science Publishers’ webpage here: http://benthamscience.com/journals/clinical-cancer-drugs/volume/3/issue/1/page/36/

Media Contact

Faizan ul Haq
[email protected]
@BenthamScienceP

http://benthamscience.com/

The post Targeting the PI3K/AKT/mTOR pathway in prostate cancer development and progression appeared first on Scienmag.

Share101Tweet8Share2ShareShareShare2

Related Posts

IMAGE

$3.25 million in grants to stand up to cancer will improve head and neck cancer treatments

January 21, 2021
IMAGE

Pre-surgery chemotherapy is possible for early stage pancreatic cancer patients

January 21, 2021

NUS scientists find new mechanism of cancer formation

January 19, 2021

Novel organoid models: Illuminating path to cervical cancers

January 19, 2021
Next Post
blank

Copper essential for burning fat, researchers find

blank

The vascular bypass revolution

Leave a Reply Cancel reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

POPULAR NEWS

  • IMAGE

    The map of nuclear deformation takes the form of a mountain landscape

    54 shares
    Share 22 Tweet 14
  • People living with HIV face premature heart disease and barriers to care

    64 shares
    Share 26 Tweet 16
  • New drug form may help treat osteoporosis, calcium-related disorders

    40 shares
    Share 16 Tweet 10
  • New findings help explain how COVID-19 overpowers the immune system

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

BiologyMedicine/HealthCell BiologyGeneticsInfectious/Emerging DiseasesTechnology/Engineering/Computer ScienceClimate ChangePublic HealthEcology/EnvironmentcancerMaterialsChemistry/Physics/Materials Sciences

Recent Posts

  • The physics behind tumor growth
  • $3.25 million in grants to stand up to cancer will improve head and neck cancer treatments
  • Estrogen receptors in mom’s placenta critical during viral infection
  • Ten suggestions for female faculty and staff during the pandemic
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms below to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In