Tag: tumor microenvironment

A new study shows that high TNFAIP3 expression in breast cancer cells drives CCL2/CCR2-mediated M2-like macrophage polarization and that combining ...

A new review details how disrupted mitochondrial homeostasis and activated retrograde signaling drive cancer progression and may open fresh therapeutic ...

Researchers built a four-gene signature based on propionate metabolism that stratifies colorectal cancer patients by survival risk and links tumor ...

A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...

A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.

A single-cell RNA sequencing study has revealed that rare ACTH- and CRH-secreting pheochromocytomas harbor a primitive Schwann cell precursor-like tumor ...

A longitudinal spatial multi-omics study reveals how the tumor microenvironment in EGFR-mutant lung cancer remodels in distinct stages as patients ...

Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...

A new computational framework quantifies why immune biomarkers that perform brilliantly in discovery datasets so often fail in clinical validation, ...

A new review in Medical Oncology maps how the tumor microenvironment and gut microbiome drive resistance to immune checkpoint inhibitors ...

A new study shows that the protein SIRPα, produced by esophageal cancer cells themselves, fuels both tumor growth and T-cell ...

A pooled analysis of four clinical trials finds that liver metastases are a strong negative prognostic factor for chemotherapy-treated pancreatic ...

An exploratory study of 61 breast cancer patients found only weak, statistically fragile links between regional tumor immune-stromal composition and ...

A new correspondence in Molecular Biology Reports highlights evidence that the adiponectin receptor agonist AdipoRon promotes angiogenesis in B-cell leukemia ...

A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...

Researchers in Japan found that high expression of the CTDNEP1 gene predicts poorer survival in clear cell renal cell carcinoma ...

Researchers report that the serotonin receptor HTR1D drives osteosarcoma metastasis and doxorubicin resistance through a c-MYC/MAPK feedback loop and CCL2/5-HT-mediated ...

A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...

The MOSAIC consortium has profiled more than 2,700 tumor samples with spatial and single-cell multi-omics to build a standardized public ...

A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...