Tag: tumor microenvironment

A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...

A new review in the Journal of Translational Medicine maps how perineural invasion may drive hepatocellular carcinoma aggression, organizing the ...

Researchers report that mitochondrial quality regulation gene activity defines two prognostically distinct breast cancer subtypes and supports a seven-gene survival ...

A new review in Molecular Biology Reports surveys how plant, microbial and animal-derived adjuvants could supercharge cancer immunotherapy by activating ...

A new iScience review argues that ferroptosis, an iron-driven form of cell death, links tumor and immune signals to muscle ...

A multimodal single-cell and spatial study has uncovered a collagen-producing fibroblast subtype enriched in EGFR-mutant non-small cell lung cancer that ...

A new review finds growing preclinical evidence that the gut microbiome can influence glioblastoma immunity, while warning that human evidence ...

A HER2-targeted mRNA lipid nanoparticle vaccine combined with fractionated radiotherapy suppressed tumor growth and reprogrammed the immune microenvironment in a ...

New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...

A spatial multi-omics study in Chinese Medical Journal shows that early gastric cancer arises within an inflammation-associated spatial niche governed ...

A new review in Cancer Cell International details how cancer-associated fibroblasts remodel the colorectal tumor microenvironment and drive resistance to ...

Danish researchers report that elevated serum levels of the macrophage-derived protein soluble CD163 independently predict shorter progression-free survival in metastatic ...

A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...

New preclinical research shows that the plant compound coumarin activates natural killer cells, boosts their mitochondrial energy supply, and shrinks ...

University of Oklahoma researchers have identified three adjacent cell subclusters in pancreatic tumors that form a feed-forward network driving cancer ...

A new review proposes co-designing oncolytic viruses and CAR-T or CAR-NK cells as a modular, self-amplifying therapeutic system to overcome ...

A new review maps how cancer-associated fibroblasts exclude immune cells from osteosarcoma tumors and outlines the therapeutic strategies that could ...

A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...

Researchers have engineered a 3D-printed hydrogel scaffold that kills residual bone tumor cells through pH-responsive nanozyme catalysis, activates antitumor immunity ...

Researchers have developed and validated a 45-gene transcriptomic signature, Met-Score, that quantifies metastatic competence in primary prostate tumors and predicts ...