Tag: tumor microenvironment

An integrated multi-omics study of 112 Chinese cervical cancer patients reveals key driver mutations, immune phenotypes, and promising therapeutic targets.

New research in Advanced Science reveals that the secreted protein LRG1 drives pathological angiogenesis in bladder cancer by binding ANXA2 ...

Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...

A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...

A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...

A new review in Cancer Reports proposes that the extracellular matrix protein COL6A1, overexpressed in the fibrotic stroma of cholangiocarcinoma, ...

A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...

A new review in Medical Oncology argues that tumor ablation can act as an in situ vaccine whose systemic power ...

A new review synthesizes single-cell chromatin accessibility studies showing that colorectal cancer is organized into two epigenomic states whose regulatory ...

A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...

A new review in iMetaMed reveals how cysteine peptidases such as cathepsins B, S, L, and X control antigen presentation ...

A new review maps the engineering strategies, from dual-target receptors to tumor microenvironment remodeling, that could finally bring CAR-T cell ...

Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, CHEK1, and NUP155 as core ...

A new Nature Reviews Urology review warns that intraductal and invasive cribriform prostate cancers are aggressive, genomically unstable and frequently ...

A new study reveals how lactate-driven lactylation of histone and non-histone proteins in liver cancer activates a METTL3-FDFT1 cholesterol pathway ...

A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...

A systematic review of 21 preclinical studies finds that curcumin and its nanoformulations modulate key cancer signaling pathways and enhance ...

A new bioinformatic study in Reproductive Sciences shows that a risk model built from telomere-related senescence genes can independently predict ...

A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...

A pan-cancer single-cell atlas of nearly 900,000 cells shows that bone metastases from ten cancer types share convergent malignant programs ...