Tag: tumor microenvironment

New research shows that high-dose vitamin C activates the JAK2-STAT1 pathway to drive macrophages toward an anti-tumor M1 state, enhancing ...

New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...

A new review in Molecular Biology Reports maps how checkpoint inhibitors, engineered cell therapies, and emerging immunotherapies are transforming treatment ...

A chiral cerium-doped mesoporous silica nanoreactor loaded with indocyanine green enables NIR-II fluorescence-guided bladder tumor surgery while amplifying reactive oxygen ...

New research shows that the oncogene ARL4C in oral cancer cells triggers a RelA-dependent inflammatory response in stromal fibroblasts, turning ...

Researchers report that adding interleukin-18 to cultures of scarce human Vδ1 T cells boosts their expansion, survival and antitumor performance ...

A marine polysaccharide hydrogel loaded with a zinc-iron MOF nanozyme and glucose oxidase induces ferroptosis and activates cGAS-STING immunity to ...

New research in Nature Communications shows that the viral RNA sensor MDA5 helps tumors evade immunity, and that disabling it ...

A microfluidic 3D tumor model reveals that glucose limits proliferation, oxygen shapes architecture, and glutamine is essential for lung cancer ...

Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...

A new review explains how E3 ubiquitin ligases attach molecular tags to the necroptosis machinery, shaping both cancer development and ...

New research in the British Journal of Cancer shows that oxygen-starved oral cancer cells activate an HMGB1-driven NLRP3 inflammasome pathway ...

Researchers at Sun Yat-sen University have mapped a hypothalamic vagal circuit through which chronic stress raises acetylcholine in liver tumors, ...

A rat study shows that spatially fractionated minibeam radiation, unlike conventional radiotherapy, preserves the efficacy of CD19-directed CAR T cells ...

A paired-sample study of 38 melanoma patients reveals that metastases undergo coordinated DNA methylation reprogramming largely independent of driver mutations, ...

A new review in Molecular Cancer argues that microbes living inside tumors dynamically reprogram immunity and can determine whether patients ...

New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...

A mechanistic model from Mass General Brigham and the University of Cyprus shows how normalizing the tumor microenvironment, without over-tightening ...

A new review argues that the mitochondrial peptide MOTS-c acts as a context-dependent stress signal with protective roles in metabolic ...

Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...