Tag: tumor microenvironment

A new review in Molecular Cancer maps how approved drugs from outside oncology could be repurposed, under a strict mechanism-first ...

An international research team reports that the sphingosine-1-phosphate signaling long thought to operate inside colorectal cancer cells instead builds an ...

A new review argues that triple-negative breast cancer's heterogeneity and therapy resistance emerge from spatially organized paracrine signaling networks between ...

A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...

Researchers have developed SpatialZoomer, a spectral graph-based tool that automatically identifies the biologically meaningful scales in spatial transcriptomics data, revealing ...

Researchers have created a zinc-crosslinked rhein and pectin hydrogel that gels inside tumors, arresting melanoma cells in the G2/M phase ...

Cold Spring Harbor Laboratory researchers found that activating the transcription factor PPARD in immune cells, including CAR T cells, boosts ...

A retrospective study found that combining a thymoma with a three-millimeter rim of surrounding tissue on CT scans improved machine ...

Two UCLA-led studies identify T-cell infiltration as the key to effective glioblastoma immunotherapy and introduce a preclinical model that recreates ...

A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...

Researchers have engineered manganese dioxide nanocarriers that degrade inside the tumor microenvironment to release methotrexate and activate DNAzyme probes, achieving ...

A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...

Researchers report that oncogenic KRAS reprograms adenosine metabolism through NT5E upregulation and ADA suppression, creating an immunosuppressive tumor microenvironment that ...

New research shows the chromatin organizer Satb1 enables regulatory T cells to promote tumor growth while remaining dispensable for preventing ...

New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...

Researchers at MD Anderson developed an AI tool called SPACER that decodes the spatial signals attracting or repelling immune cells ...

Researchers at Tokushima University found that combined TP53 and CDKN2A mutations activate cGAS–STING-mediated antitumor immunity, delaying progression to invasive oral ...

Two patients with microsatellite-unstable metastatic colorectal cancer and markedly reduced HLA-I expression achieved durable responses to pembrolizumab, suggesting that NK ...

An interpretable machine learning framework called SPACER decodes the gene-level rules that recruit or exclude immune cells in tissues, revealing ...

A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...