Tag: tumor microenvironment

A machine learning analysis of inflammation and metabolism genes across seven lung adenocarcinoma cohorts identifies the calcium pump gene ATP2A2 ...

Single-cell RNA sequencing of hepatocellular carcinoma reveals that MRC1-positive macrophages, endothelial capillarization, and strengthened PTPRM signaling define the tumor ecosystem ...

A new review explains why BCG immunotherapy fails in some bladder cancer patients and outlines emerging combination strategies designed to ...

A new review in Cellular and Molecular Life Sciences maps the molecular pathways, immune microenvironment and AI-driven technologies that shape ...

A Mendelian randomization study of 119 gut microbial genera finds six suggestive inverse associations with non-small cell lung cancer risk, ...

Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...

A toxicogenomic reanalysis links acrolein-responsive gene dysregulation to immune-stromal heterogeneity in colorectal cancer, supported by single-cell localization and RT-qPCR validation ...

A new perspective highlights that while 3D bioprinted melanoma models closely mimic real tumors, outdated two-dimensional analysis methods are undermining ...

A machine-learning-assisted reanalysis of single-cell and bulk transcriptomic data provides a reproducible framework for characterizing glioblastoma ecosystem states while carefully ...

A systematic review finds that nanoparticles conjugated with fibroblast activation protein inhibitors show strong preclinical promise for targeted cancer imaging ...

New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...

A dual-photosensitizer light treatment combined with optical clearing eradicated thick pigmented melanoma in mice by triggering a potent, long-lasting anti-tumor ...

New research links the secreted glycoprotein LGALS3BP to selective enrichment of microRNAs and the RNA-binding protein SRSF1 in neuroblastoma extracellular ...

A comprehensive Molecular Cancer review explains how antibody-drug conjugates deliver lethal payloads to tumors, why resistance emerges, and which next-generation ...

Roche researchers validate a human 3D immune-containing colorectal cancer assembloid platform that captures interferon-gamma signaling, uncovers fibroblast plasticity, and demonstrates ...

A new review argues that cancer cells toggle between glycolysis and mitochondrial respiration in hybrid metabolic states, and that mapping ...

A comprehensive Chinese Medical Journal review led by Professor Feng Wang synthesizes five years of advances in esophageal cancer, highlighting ...

Researchers in Milan have identified MyD88 as a tumor cell-intrinsic switch that sustains a metastasis-competent, integrin-driven cell state in NRAS-mutant ...

Japanese researchers have built a microfluidic chip that uses human macrophages as living biological transducers, converting unknown cancer-cell-derived signals into ...

A 34-year bibliometric analysis of 1,847 publications reveals booming research on Chinese patent medicines in breast cancer care, alongside a ...