Engineered Dendritic Cell Vaccine Draws Immune Cells Into Lung Tumors but Falls Short of Shrinkage
A phase I trial found that a CCL21-engineered dendritic cell vaccine combined with pembrolizumab safely increased T cell infiltration in ...
Tag: tumor microenvironment
Hidden Immune Signal RSAD2 May Drive Endometrial Cancer Growth, Study Finds
A multi-omics study links the antiviral protein RSAD2 to CXCL1–CXCR1/2 signaling that recruits macrophages and drives endometrial cancer progression.
Bladder Cancer Protein GSDMB Boosts Immunotherapy by Recruiting Immune Cells
A new study reveals that the protein GSDMB enhances anti-PD-1 immunotherapy in bladder cancer by driving Sema7a-mediated recruitment and activation ...
Tiny Droplets Inside Cells Could Decide Whether Cancer Therapy Works
A new review in Molecular Cancer synthesizes how liquid-liquid phase separation shapes radiosensitivity, immune evasion, and treatment resistance in cancer.
ENO3 Emerges as a Lactate-Linked Biomarker in Colorectal Cancer Metastasis
Integrated transcriptomic analysis of TCGA and GEO datasets identifies a six-gene lactate metabolism signature and nominates ENO3 as a prognosis-associated ...
DNA repair kinase PRKDC helps liver cancer hide from macrophage attack
A new study reveals that PRKDC, a gene known for DNA repair, drives immune evasion in hepatocellular carcinoma by pushing ...
Induced Pluripotent Stem Cells Take Aim at Cancer Prevention, Therapy, and Tumor Modeling
A new review highlights how induced pluripotent stem cells are being engineered into immune cells, cancer vaccines, and tumor models ...
Cancer’s Deadly Spread Takes Center Stage at UVA’s Weber Symposium
The University of Virginia Comprehensive Cancer Center's sixth-annual Michael J. Weber Symposium on Oct. 2 will bring together leading researchers ...
Silenced Thyroid Gene CRABP1 Signals Aggressive Cancer Cells, Study Finds
A single-cell and epigenetic study links loss of the retinoid-binding protein CRABP1 to an invasive malignant epithelial cell state in ...
Plant Vesicles Turn Herbal Cancer Drugs Into Precision Weapons
A new review argues that plant-derived extracellular vesicles can both deliver and amplify the anticancer power of plant natural products, ...
Neutrophils: The Double-Edged Immune Cells Shaping Oncolytic Virus Therapy
A new review reveals how neutrophils can either enhance or undermine oncolytic virus therapy through N1/N2 polarization, virus delivery, and ...
Copper Overload Triggers a Distinct Form of Cell Death That Could Transform Cancer Therapy
A new review details how excess copper induces cuproptosis, a mitochondria-dependent form of cell death that cancer cells are uniquely ...
Continuous Immune Composition Outperforms Coarse Labels in Tracking Pediatric Leukemia Over Time
A new Bayesian analysis of single-cell pediatric leukemia data shows that continuous B-lineage immune composition carries longitudinal information that coarse ...
How Far a Tumor Sits From the Serosa May Reveal Hidden Aggressiveness in Colon Cancer
A new study finds that the microscopic distance between a T3 colon tumor and the serosal surface is linked to ...
Mutant Blood Cells May Quietly Raise the Risk of Six Cancers, Genetic Study Finds
A large Mendelian randomization study links genetically predicted clonal hematopoiesis of indeterminate potential to increased risks of six cancer types, ...
NK Cell Immunotherapy for Solid Tumors Advances, but Cardiac Safety Questions Remain
A new review maps the rapid rise of NK cell immunotherapy for solid tumors and warns that its cardiovascular safety ...
Inflammation Gene Variant May Shape Survival After Rectal Cancer Therapy Choice
An exploratory analysis of a randomized trial in locally advanced rectal cancer found that an IL1B gene variant was linked ...
Cancer’s Master Switch: New Map Reveals How Tumors Outsmart Immunotherapy
A sweeping new review in Molecular Cancer maps the PD-1/PD-L1 axis from immune evasion mechanisms to next-generation therapeutics, offering a ...
SRPX2 Emerges as a Master Switch Behind Colorectal Cancer Spread and Immune Evasion
New research identifies the secreted protein SRPX2 as a molecular switch that stabilizes the TGF-beta receptor to drive metastasis and ...
Zinc Peroxide-Coated Gold Nanorods Turn Tumors From Cold to Hot by Fusing Photothermal Heat, Chemodynamic Radical Attack, and Metal Ion Immune Signaling
Researchers have engineered a zinc peroxide-coated gold nanorod that combines photothermal heating, self-supplied chemodynamic radicals, and zinc-driven cGAS-STING immune activation ...
