Three microRNAs reveal breast cancer resistance patterns
A review finds that miR-125b, miR-375 and miR-451 are linked to breast cancer chemoresistance through distinct, context-dependent mechanisms that require ...
Tag: tumor microenvironment
Single-Cell Sequencing Extends Tumor Analysis to Fixed Clinical Samples
A Roche-led benchmark found that the 10X Genomics GEM-X Flex assay with chop-fix processing improves single-cell RNA profiling of frozen ...
Single-cell map reveals lncRNA networks shaping cancer outcomes
A pan-cancer single-cell framework identifies 667 cell-specific long noncoding RNAs and thousands of functional pairs linked to tumor heterogeneity and ...
Spatial epigenomics reveals stromal niche-associated regulatory programs across pancreatic neuroendocrine tumor grades
A combined single-nucleus and spatial ATAC-seq study maps grade-associated chromatin regulatory programs in non-functional pancreatic neuroendocrine tumors, revealing spatially organized ...
New Study Identifies UBA1 as a Key Biomarker in Multiple Myeloma
A new study identifies UBA1 as a primary candidate biomarker for multiple myeloma by integrating ubiquitination and liquid-liquid phase separation ...
AI Model SPACER Decodes the Hidden Rules of Cell Recruitment in Human Tissue
An interpretable deep learning model called SPACER reads spatial transcriptomics data to reveal the molecular and spatial rules that govern ...
Silent Interferon Signals May Flag Ovarian Tumors That Shrug Off Chemotherapy
A cautious reanalysis of single-cell, TCGA, MRI, and cell-line data links muted type-I interferon signaling and altered cell-state programs to ...
MiR-145 emerges as a driver and biomarker of the fibrotic tumor microenvironment
A new study identifies miR-145 as a driver and biomarker of the fibrotic tumor microenvironment, linking NOTCH signaling, promoter hypomethylation, ...
Turning liver tumor ablation into a vaccine: the immune logic behind a new HCC strategy
A new review explains how tumor ablation triggers a transient immune response in liver cancer and why combining it with ...
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Cancer’s Metabolic Battleground: How Immunometabolism Became Immunotherapy’s Next Frontier
A systematic bibliometric review of more than 3,200 publications reveals that tumor immunometabolism research has surged since 2020, shifting from ...
Protease Inhibitors May Finally Crack Cancer’s Drug Resistance Problem
A new review argues that proteases drive chemoresistance through drug transport, matrix remodeling, and cell death signaling, and that precision-targeted ...
Personalized Cancer Spheroids Bring Tumor Reality Into the Lab
A new review highlights how patient-derived 3D cancer spheroids could transform precision oncology by recreating tumor architecture, drug resistance, and ...
AI Reads the Whole Lung to Predict Which Cancer Patients Will Benefit From Immunotherapy
Researchers developed a whole-lung radiomics AI model that predicts which lung cancer patients will achieve complete pathological response to neoadjuvant ...
Ovarian Cancer Cells Depend on USP15 Enzyme, Offering a Sharper Therapeutic Target
UMBC researchers found that ovarian cancer cells depend heavily on the enzyme USP15, and reducing it slows tumor growth, disrupts ...
Lactate-Driven Epigenetic Shifts Reshape Liver Cancer Immunity
New research reveals that lactate-driven histone lactylation promotes Treg/Th17 imbalance in liver cancer via the PTPRM-STAT3 axis.
Nerve Signal Neuromedin U Shields Aggressive Prostate Cancer From Immune Attack
Wistar Institute researchers found that the neurotransmitter neuromedin U suppresses T cell infiltration at the earliest stage of neuroendocrine prostate ...
How Stroke Injury Feeds the Brain’s Deadliest Tumors
A new Nature Cancer study shows that stroke remodels the brain's tumor microenvironment, creating tumor-associated astrocytes and macrophages that drive ...
Six-Gene Signature Predicts Breast Cancer Prognosis and Immune Status
A new six-gene signature derived from weighted gene co-expression network analysis predicts breast cancer survival and characterizes the tumor immune ...
Scientists Map Two Distinct T Cell Exhaustion Programs Driving AML Relapse Before and After Transplant
Single-cell sequencing reveals that self-derived and donor-derived exhausted T cells in acute myeloid leukemia run on different transcriptional programs, with ...
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