Stable MRI Radiomics Predicts Chemotherapy Response in Breast Cancer
A retrospective multicenter study of 686 patients with HR+/HER2− breast cancer established a stability-driven MRI radiomics model that accurately predicted ...
Tag: tumor heterogeneity
Subcellular RNA Patterns Improve Cell Clustering in Spatial Transcriptomics
A new graph autoencoder framework called SPICEiST enhances cell clustering in imaging-based spatial transcriptomics by integrating subcellular RNA patterns with ...
Tumor heterogeneity shapes responses to STING and LTβR-mediated TLS induction
A new study shows that tumor heterogeneity significantly impacts the success of STING and LTβR-mediated tertiary lymphoid structure induction in ...
MRI Radiomics and Vascular Gene Profiles Capture Different Sides of Breast Cancer Tumor Blood Vessels
A study of 932 breast cancer patients finds that DCE-MRI radiomic subgroups and vascular gene-expression subgroups capture complementary, non-overlapping dimensions ...
Extrachromosomal DNA Emerges as Possible Breast Cancer Liquid Biopsy Marker
A new review finds plasma extrachromosomal DNA may complement cell-free and circulating tumor DNA measures in breast cancer liquid biopsy, ...
Four Radiomic Texture Features Survive the Leap from Clinical CT to Micro-CT in Lung Cancer
A study of 60 NSCLC patients finds that only four texture-based radiomic features remain reproducible across clinical CT, ex vivo ...
Metabolic Rewiring Emerges as a Central Driver of Liver Cancer Growth and Treatment Resistance
A new review argues that glucose, lipid, and amino acid metabolism form one interconnected network driving hepatocellular carcinoma growth, immune ...
Preclinical plug-and-play CAR T cells can be reconfigured after treatment
An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment, ...
Cysteine Dependence Reveals Metabolic Weakness in Small Cell Lung Cancer
Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...
BRCA Mutations Shape Immune Landscapes in Ovarian Cancer, Spatial Study Finds
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
Five Aptamers Show Activity Against Triple-Negative Breast Cancer Cells
A five-aptamer panel reduced tumor-cell viability, proliferation, migration and colony formation in several triple-negative breast cancer cell lines, with variable ...
AI Maps Cell-State Gene Networks in Cancer, but Causation Still Requires Experiments
A mini-review finds that AI-assisted reconstruction of cell-state-specific gene regulatory networks can illuminate tumor plasticity and drug resistance, but experimental ...
EGFR Co-Targeting with Nanocarriers Offers New Precision Path for Triple-Negative Breast Cancer
A new review in Genes & Diseases outlines how co-targeting EGFR alongside other tumor-driving molecules, delivered via nanocarriers, could enable ...
AI Reads Lung CT Scans to Predict Drug Resistance Before Treatment Begins
A Chinese research team combined delta-radiomics from CT scans with clinical data and SHAP-based machine learning interpretation to predict the ...
AI Reads Liver Scans to Predict Which Colorectal Cancer Patients Will Respond to Chemotherapy
Researchers in China have developed an interpretable machine learning model that analyzes all liver metastases on contrast-enhanced CT scans to ...
Two PET scans may outsmart a single biopsy in predicting aggressive neuroendocrine cancer outcomes
A new study shows that discordant lesions on dual-tracer FDG and FAPI PET/CT strongly predict shorter progression-free survival in aggressive ...
Cancer’s Hidden Fingerprints: Tumor DNA Found in Body Fluids Beyond Blood
A new study shows that sequencing tumor DNA in ascites, pleural fluid, cerebrospinal fluid, and pericardial effusions can detect malignancies ...
Hidden Cell-to-Cell Messaging Networks Drive Triple-Negative Breast Cancer Resistance
A new review argues that triple-negative breast cancer's heterogeneity and therapy resistance emerge from spatially organized paracrine signaling networks between ...
Tumor Twins: Living Lab-Grown Cancer Copies Paired With AI Could Transform Breast Cancer Treatment
A new review in Cellular and Molecular Life Sciences proposes hybrid biological-digital tumor twins, coupling patient-derived organoids with computational models ...
Pancreatic Cancer Cells Constantly Rewrite Their DNA to Outsmart Treatment
A single-cell analysis of nearly half a million pancreatic cancer cells shows that continuously evolving clones reshape their DNA to ...
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