TROP2 Drives Hypopharyngeal Cancer Growth by Blocking Pyroptosis Through PI3K/AKT
A new study reports that TROP2 suppresses pyroptosis through the PI3K/AKT pathway, promoting hypopharyngeal squamous cell carcinoma progression.
Tag: TROP2
Targeted Radiopharmaceuticals Are Reshaping Precision Cancer Therapy
A new review maps how target-specific radiopharmaceuticals pair matched diagnostic and therapeutic radionuclides to deliver precision cancer therapy from imaging ...
CAR-NK Cells Engineered to Intercept Breast Cancer Metastasis
A new review in Breast Cancer Research outlines a framework for engineering CAR-NK cells to intercept circulating tumor cells, target ...
Detailed safety analysis shows sacituzumab tirumotecan manageable in metastatic triple-negative breast cancer
A post-hoc safety analysis of the phase 3 OptiTROP-Breast01 trial found that sacituzumab tirumotecan's key adverse events arose mainly in ...
VCU grant funds study of TROP2-targeted drugs in breast and pancreatic cancers
A five-year National Cancer Institute grant will fund laboratory research into response biomarkers and resistance mechanisms for TROP2-targeted antibody-drug conjugates ...
Antibody–drug conjugates and tumor immunity in breast cancer
A focused review finds that antibody–drug conjugates directly kill breast-cancer cells, while evidence that they remodel human tumor immunity remains ...
TROP2: A Target for Cisplatin-Resistant Germ Cell Tumors
Recent studies have highlighted the complexities and challenges in treating germ cell tumors, particularly those that exhibit resistance to standard ...
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