PET tracer tracks activated T cells during STING agonist immunotherapy trial
A four-patient PET study found that the activated T cell tracer F-AraG is best quantified with a two-tissue irreversible model ...
Tag: T cell activation
Lck kinase fine-tunes T cell activation by phosphorylating autophagy receptor p62
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
From Spectra to Clinical Insight: Raman Spectroscopy in Kidney Transplant Monitoring and Donor Assessment
A review of human, animal and laboratory evidence shows that Raman spectroscopy and SERS can detect molecular patterns associated with ...
STAT3 directly silences Ets-2 to enable IL-2 in activated T cells
A study in Jurkat T cells found that activated STAT3 binds the Ets-2 promoter, reduces expression of a transcriptional silencer, ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
Common Sweetener Sucralose Shows Surprising Ability to Calm Autoimmune Attacks in Vitiligo
New research shows the artificial sweetener sucralose slows autoimmune depigmentation in mice and suppresses human CD8+ T cell activity by ...
Electric Pulses Beat Heat and Cold at Turning Dead Tumor Cells Into Cancer Vaccines
A controlled in vitro study shows irreversible electroporation induces stronger dendritic cell activation and T cell proliferation than cryoablation or ...
AI Watches CAR T Cells Destroy Tumors in Real Time Inside Patient-Derived Organoids
Researchers have combined patient-derived pancreatic tumor organoids with a deep learning algorithm called OrganoIDNet to automatically track in real time ...
Whole-Body Computer Model Aims to Pinpoint the Best Way to Vaccinate Each Cancer Patient
Researchers have built a whole-body computational model that simulates how vaccination site, timing, and tumor-derived suppression shape anti-cancer immune responses, ...
Trispecific Antibody Boosts T Cell Anti-Tumor Response
In the realm of oncology, the challenges posed by immunologically unresponsive tumors have remained a significant hurdle, particularly in the ...
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