Clonal Hematopoiesis Links Environmental Toxicant Exposures to Long-Term Disease Risks
A scientific review identifies clonal hematopoiesis as a measurable biological bridge connecting toxic environmental exposures to long-term health risks.
Tag: somatic mutations
Review Explores Role of Somatic Mutations in Neurodegenerative Disease Mechanisms
A review in BMC Biology examines how advanced sequencing and computational tools detect ultra-rare somatic mutations and investigate their causal ...
Study Uncovers Distinct Somatic Mutations in Bernese Mountain Dog Lymphomas
Targeted genomic analysis of 27 Bernese Mountain dog lymphomas identified somatic mutations in over 96 percent of cases, revealing recurrent ...
Targeted Deep Sequencing Tracks Y Chromosome Loss and Blood Clones Together
A targeted deep sequencing method simultaneously estimates mosaic Y chromosome loss and CHIP-related mutations, validated in over 400 male patients ...
New method reads sequencing errors directly from overlapping reads to spot rare mutations
A new method called BBQ learns sample-specific sequencing error patterns from overlapping paired-end reads and improves the precision of low-frequency ...
Cancer genome profiling uncovers hidden inherited cancer risk in one in ten patients
A prospective trial found constitutional pathogenic variants in about 10 percent of solid tumor patients screened through comprehensive cancer genome ...
Chemotherapy and radiotherapy reshape evolution in healthy oesophagus tissue
Genome sequencing of normal oesophageal tissue shows that chemotherapy and chemoradiotherapy select for distinct mutant clones in healthy cells, including ...
Review finds stronger causal evidence for senescence than mutations in aging
A literature review finds stronger experimental support for cellular senescence as a cause of age-related decline than for somatic DNA ...
Urine DNA Pilot Finds Cervical Cancer-Associated LOH Signals
Two small Sudanese pilot studies found cervical-cancer-associated LOH signals in urine, including four women with normal or non-atypical Pap smears, ...
Alzheimer’s tetraploid neurons show enriched somatic single nucleotide variants
A six-brain sequencing study found that Alzheimer’s-associated tetraploid neurons carried excess low-frequency somatic single nucleotide variants, with enrichment for T>C ...
Blood Cell Mutations Raise Risk of Dangerous Bacterial Infections, Giant Study Finds
A study of nearly 900,000 people shows that acquired blood stem cell mutations, particularly expanded SRSF2 clones, confer mutation- and ...
Inflammageing and Clonal Haematopoiesis: Disease Connections
Clonal haematopoiesis of indeterminate potential (CHIP) is emerging as a significant area of investigation within the context of age-related diseases, ...
New Insights into the Earliest Stages and Potential Triggers of Stomach Cancer Uncovered
In a groundbreaking study recently published in the journal Nature, a collaborative team of scientists has conducted an in-depth analysis ...
Saudi Arabians: Somatic mutations in breast cancer: New opportunities
'Worldwide, breast cancer is the most common cancer in women.' Oncotarget published "Landscape of somatic mutations in breast cancer: new ...
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