A molecular stratification of endoplasmic reticulum stress in lung adenocarcinoma identifies DKK1 as a tumor-cell-biased prognostic regulator linked to ER-phagy-related ...
A new mini-review proposes that durable senescence-like states in dorsal root ganglion sensory neurons may help explain why pain persists ...
A new review proposes that mature tumor cells can dedifferentiate into cancer stem cells, acting as a non-genetic engine of ...
A new review argues that stem cell grafts can protect tissue and communicate with host circuits in selected spinal cord ...
A four-gene transcriptomic signature stratifies prostate cancer patients by biochemical recurrence risk and identifies SPAG5 as a targetable oncogene.
A UK Biobank study linked 681 blood proteins to cardiac MRI phenotypes and used genetic analysis to prioritize potentially causal ...
A Phase II trial in Japan identified TCR signaling mutations and clonal hematopoiesis burden as biomarkers predicting dasatinib response in ...
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
A new single-cell transcriptomic atlas of testicular mixed germ cell tumors identifies 13 major cell types, m6A machinery upregulation and ...
A new dual-view machine learning framework called scTrans-SVD achieved a mean Macro-F1 of 0.8820 across 13 public single-cell transcriptomic datasets ...
An exploratory genomic framework combining Mendelian randomization, kidney-compartment eQTL data, and colocalization identifies seven candidate genes for kidney traits, with ...
A multi-omics study finds that liver fibrosis involves coordinated cell-type-specific metabolic remodeling, and that the phospholipid POPE reduces hepatic stellate ...
A multi-omics study identifies macrophage ALOXE3 as a modulator of oxidative stress in acetaminophen-induced liver injury, with overexpression reducing liver ...
A new multi-omics study reports that myricetin from Myrica rubra binds HSP90AA1, suppresses PI3K–Akt signaling and inhibits bladder cancer growth ...
A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.
A new study explains how variational autoencoders integrate multimodal biomedical data and reveals key limitations of in silico perturbation analyses.
A computational study combining transcriptomics, machine learning and single-cell analysis identifies CYP1B1 as a potential functional target of kaempferol in ...
A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...
A retrospective Chinese study reports that all 11 patients with lymph-node-dominant metastatic gallbladder cancer responded to PD-1 blockade plus gemcitabine ...
A new review describes how tumors reprogram Schwann cells into states linked to perineural invasion, matrix remodeling and altered immune-cell ...
