New mouse tool targets microvascular endothelial cells in muscle and fat
Scientists have created a CTRP9-CreERT2 knock-in mouse line whose tamoxifen-inducible reporter selectively labels microvascular endothelial cells in heart, skeletal muscle, ...
Tag: single-cell RNA sequencing
Endothelial TXNIP emerges as a driver of pulmonary vascular remodeling
A new study reports that inhibiting the protein TXNIP in pulmonary vascular endothelial cells attenuates pulmonary hypertension and vascular remodeling ...
Three genes tied to lactylation and lactate metabolism may flag prostate cancer recurrence risk
An integrated sequencing analysis identified MKI67, MIPEP and CCNA2 as candidate prognostic biomarkers for biochemical recurrence risk in prostate cancer.
Exercise Reshapes T-Cell Gene Activity in Diabetes, Study Finds
A new study links exercise-responsive genes, including JUNB, to T-cell state changes and cardiac transcriptional responses in type 2 diabetes.
Blood CXCL1 tracks Salmonella colonization in tumors, study finds
Sustained blood CXCL1 elevation tracked attenuated Salmonella colonization in four preclinical tumor models.
Same RSV antigen, two vaccine platforms, two different immune maps in mice
In a head-to-head mouse study, an adenoviral RSV vaccine built stronger systemic immunity while a self-amplifying RNA vaccine preferentially established ...
Dexmedetomidine Curbs Chemotherapy-Related Heart Fibrosis in Mouse Study
A mouse and cell study finds dexmedetomidine reduces doxorubicin- and trastuzumab-induced myocardial fibrosis by promoting Serpine1 and regulating the STAT3/Notch-1 ...
Single-cell map reveals how EV-derived miRNAs shape the liver cancer microenvironment
A computational analysis of single-cell RNA sequencing data maps 208 prognosis-linked miRNA-target pairs carried by extracellular vesicles in the hepatocellular ...
Single-cell insights into plant responses to biotic and abiotic stresses: cellular heterogeneity and regulatory mechanisms
A new review in Plant Cell Reports synthesizes how single-cell and spatial omics technologies reveal distinct cellular strategies plants use ...
New Rat Model of Ovarian Endometrioma Reveals Cellular Damage to the Ovary
A new rat model of ovarian endometrioma combined with single-cell RNA sequencing reveals granulosa cell dysfunction, stromal fibrosis, and immune ...
Timing decides which influenza lineages win, cell-culture study finds
A single-cell barcoding study in A549 cells shows that influenza A virus lineage enrichment occurs mainly during synchronous co-infection, within ...
AhR blockade rewires myeloid–T cell crosstalk and boosts anti-PD-1 response in preclinical tumor models
Preclinical research shows that blocking the aryl hydrocarbon receptor reshapes myeloid–T cell crosstalk and enhances anti-PD-1 responses across mouse and ...
PLPP4 marks a fibroblast subset that fuels tumor growth through excess matrix deposition
Researchers identified PLPP4 as a functional marker of an ECM-enriched cancer-associated fibroblast subset that promotes tumor growth and metastasis via ...
Immune-cell study hints IL-1β macrophages may fuel pro-tumor signals in liver cancer
Single-cell and multi-omics analyses of hepatocellular carcinoma point to IL-1β-positive macrophages and IL-1R1-positive inflammatory fibroblasts as putative drivers of a ...
Culture Medium Rewrites Drug Sensitivity in Patient-Derived Tumor Organoids
A new study shows that the choice between Wnt-based and OncoPro culture medium reshapes the transcriptional state and drug sensitivity ...
Thyroid Hormone Carrier TTR Pushes Young Brain Stem Cells Toward Differentiation in Mice
A mouse study finds that exogenous transthyretin shifts postnatal subventricular zone progenitors toward differentiated states through pathways that partially converge ...
CXCR4 emerges as a dermal immune signal hub in psoriasis, single-cell and spatial study finds
An integrated single-cell and spatial transcriptomics study finds CXCR4 concentrated in dermal immune cells of psoriatic skin and identifies a ...
Engineered T-BET Pushes Lab-Grown NK Cells Toward Inflammation, Not Full Maturity
Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation ...
Tumor cell program tied to lymphatic responses in aggressive thyroid cancer
A multi-omics study links an extracellular matrix-associated epithelial state and a SERPINA1–SOX4–FN1 molecular axis to lymphatic endothelial responses in papillary ...
Single-cell atlas reveals inflammatory monocyte state tied to WTAP in healthy lungs and COPD
A single-cell atlas of healthy and COPD lung tissue identifies an HSPA1B-positive inflammatory monocyte state whose transcriptional program is associated ...
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