Tag: RNA splicing

In triple-negative breast cancer cell lines and organoids, pharmacologic targeting of the splicing factor RBM39 disrupts mitotic fidelity and increases ...

New research in Nature finds that 33 of 34 lupus patients carried neutrophils with RNA splicing mutations producing neoantigens that ...

A peer-reviewed experimental study finds that RNA-scaffolded SFPQ condensates gather factors involved in transcription, splicing and chromatin regulation, with disrupted ...

A multi-omics study linked ELF1 to B-cell states and breast-cancer prognosis, with cohort associations and laboratory experiments supporting further biological ...

A mouse study links high-fat feeding to reduced PQBP1, altered synaptic-gene RNA splicing, and impaired cognition while showing that restoring ...

A single-patient study showed that a deep intronic MFSD8 variant causes CLN7 disease by triggering abnormal pseudoexon inclusion that disrupts ...

Harvard-led researchers developed a transcriptomic aging clock to screen rejuvenation genes and found that over-expressing the RNA splicing factor SRSF1 ...

A new study shows that alternative splicing, especially through microexons shorter than five amino acids, fine-tunes protein interaction interfaces to ...

A genome-wide study identifies 9,814 poison exons in the human genome and shows that hundreds are brain-specific, linking their mis-splicing ...

A new review in the Journal of Neurology charts the rapid evolution of treatments for myotonic disorders, from established sodium ...

A new study shows that synonymous PROS1 variants once considered harmless can cause Protein S deficiency through aberrant splicing and ...

A conserved Lsm8-exosome module that safeguards RNA splicing fidelity has been revealed as a master switch controlling growth, stress adaptation, ...

Study clarifies why some proteins 'flock together' in the nucleus Almost all cells in our body contain a nucleus: a ...