TERRA R-loops turn chromosome ends into cancer’s weak spot
A new review explains how TERRA-driven R-loops at telomeres can either protect chromosome ends or fuel replication stress, genomic instability ...
Tag: Replication stress
Cediranib plus KRASG12C inhibitors triggers replication stress and antitumor immunity
A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...
Replication stress marker points to ovarian cancers that may yield to ALC1 targeting
New research shows that removing the chromatin remodeler ALC1 sensitizes a broad range of ovarian cancer models to PARP inhibitors ...
NAT10 enzyme adds ketone-derived tag to histones to speed DNA replication
A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...
Cohesin reorganizes stressed DNA replication sites to protect genome stability
An experimental cell study finds that cohesin rapidly reorganizes stressed DNA replication sites and suppresses an error-prone restart pathway, helping ...
Cytomegalovirus Hijacks Host Chromatin Remodeler MORC2 to Fuel Viral Genome Repair
A new PLOS Pathogens study shows that human cytomegalovirus induces and recruits the host chromatin remodeler MORC2 to viral replication ...
DNA Repair Enzyme Pol ι Emerges as Key Player in Early Breast Cancer Risk in BRCA2 Carriers
A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, where it ...
Cancer’s Rogue DNA Can Backfire, Trapping Oncogenes in Micronuclei and Slowing Tumors
New research shows that damaged extrachromosomal DNA is trapped in transcriptionally silent micronuclei, impairing cancer cell fitness and predicting better ...
ATR Inhibitor Ceralasertib Paired With Olaparib Shows Promise in BRCA-Mutant Breast Cancer
A Phase 1 trial found that combining the ATR inhibitor ceralasertib with the PARP inhibitor olaparib was generally well tolerated ...
Revolutionary Cryo-Electron Microscopy Unlocks Secrets of DNA Replication and Illuminates New Cancer Treatment Targets
Every day, our bodies engage in a remarkable process of cellular division, where billions of cells are replaced to ensure ...
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