Local Immune Modulation and Vector Selection Dictate Gene Therapy Efficacy for Dent Disease
A preclinical study demonstrates that local rapamycin microsphere delivery enables durable lentiviral gene therapy for Dent disease type 1 in ...
Tag: Proteinuria
SGLT2 inhibitor stabilized kidney function in teen on cisplatin
A case report describes an adolescent with metastatic germ cell tumor whose kidney function stabilized and intravenous magnesium needs ended ...
GLP-1 Receptor Agonists Show Kidney Protection in Lupus-Prone Mice
Liraglutide reduced proteinuria and kidney injury in lupus-prone mice through anti-inflammatory, antioxidant, and ferroptosis-related mechanisms, with cAMP signaling implicated.
First-in-human trial of TEAD inhibitor BPI-460372 shows early signals and safety limits
A first-in-human phase Ia trial reports that the covalent TEAD palmitoylation inhibitor BPI-460372 showed preliminary antitumor activity in advanced solid ...
Belimumab add-on therapy eased fatigue and disease activity in Saudi lupus cohort over 12 months
A prospective 12-month cohort study of 36 Saudi patients with lupus found that belimumab add-on therapy was associated with significant ...
TRPC5 staining marks heterogeneous FSGS biopsy phenotype in clinical cohort
A retrospective FSGS biopsy cohort found that heterogeneous TRPC5 staining was associated with poor treatment response and kidney failure, while ...
Reduced fruquintinib dose showed no significant survival association in colorectal cancer cohort
In a multicenter retrospective cohort of 69 patients with refractory metastatic colorectal cancer, an initial fruquintinib dose below 5 mg ...
How Infection Signals Push Kidney Filter Cells Into Leaks, Damage, and Cell Death
New research shows that sustained activation of the innate immune receptor TLR4 in podocytes triggers a reversible leak in the ...
Finerenone Slows Kidney Decline in Non-Diabetic CKD, Real-World Study Finds
A 24-month real-world cohort study of 121 patients with non-diabetic chronic kidney disease found that finerenone initiation was associated with ...
Kidney Damage Emerges as Hidden Complication in Beta-Thalassemia Survivors
A clinical study finds that albuminuria and proteinuria are common in beta-thalassemia major patients and vary with age and iron ...
Inflammatory Fatty Acid Drains Kidney Cells’ Energy Supply, Worsening Podocyte Damage
New research shows that arachidonic acid released during infection worsens podocyte kidney injury by disrupting PKM2-linked glycolytic metabolism and mitochondrial ...
Kidney Cells Switch On a Cholesterol Program When Flooded by Protein, Study Finds
A donor-aware single-cell analysis links membranous nephropathy to an LXR-linked cholesterol-handling state in kidney tubule cells and reveals a matching ...
RNA Chemical Tag Emerges as Hidden Driver of Kidney Damage in Diabetes
A new study shows that the RNA demethylase FTO stabilizes EGR1 mRNA through m6A modification, activating a STING1-driven inflammatory cascade ...
Kidney Biomarkers Face a Reckoning: New Study Asks What Doctors Really Need From AKI Tests
A new Pediatric Research study and accompanying commentary argue that kidney injury biomarkers must be judged by the specific questions ...
RNA-Binding Protein PTBP3 Drives Kidney Scarring in Diabetes, Study Finds
Researchers at Harbin Medical University report that the RNA-binding protein PTBP3 stabilizes SMAD3 mRNA and drives podocyte epithelial-to-mesenchymal transition, and ...
Rising RNA Signal in Blood May Track Diabetic Kidney Damage in Egyptian Patients
A new study of Egyptian patients with type 2 diabetes finds that serum levels of the long noncoding RNA PVT1 ...
Reevaluating Proteinuria as a Key Endpoint in IgA Nephropathy
A groundbreaking study conducted by a team of researchers led by Maillard, El Karoui, and Mercer has unearthed critical insights ...
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