Tag: Protein Stability

Researchers discovered that budding yeast cells regulate the translation of their essential Cdk-activating kinase through an upstream open reading frame ...

Researchers evaluated how excipient ratios and moisture exposure dictate the physical, chemical, and functional stability of spray-dried antibody fragments designed ...

A genome-wide CRISPR screen reveals that the UBE2K-FBXO11 complex stabilizes beta-catenin through K63-linked polyubiquitination to promote Wnt signaling and cancer ...

A computational investigation prioritizes high-risk nonsynonymous mutations in SLC22A transporter genes that may alter protein stability and metformin pharmacokinetics in ...

A study published in Cellular Oncology reveals that OTUD1 stabilizes SLC7A11 via deubiquitination to suppress ferroptosis and promote lenvatinib resistance ...

A compact energy-based neural network called LEEN predicts protein stability changes from single amino acid substitutions using roughly 2 to ...

Researchers developed ESMTmP, a multiscale multitask learning model that predicts protein melting temperatures with reduced error and order-consistent outputs.

Overlapping deep mutational scanning experiments were fused into a consensus variant soundness score that trained ESMRank, a sequence-based learning-to-rank model ...

ZNF207 stabilizes the glutamine transporter ASCT2 by blocking SPOP-driven ubiquitin-proteasome degradation, sustaining AKT/mTORC1 signaling in hepatocellular carcinoma cells.

A computational analysis of more than 1,000 FOXE1 variants identified 37 high-risk candidates, most predicted to reduce protein stability, with ...

A new plasma-derived fibrinogen concentrate manufactured with an added UV-C irradiation step retained near-full activity, high purity and five-year stability ...

A review describes how RXLR effectors from the potato late blight pathogen target multiple immune and cellular processes that support ...

A new study shows that sugar-based chemical interactions, rather than molecular crowding size, help the glycolytic enzyme PFKP stay active ...

By swapping every valine in the protein GB1 for fluorinated analogues, researchers used fluorine-19 NMR, three-bond coupling constants and gamma ...

A large-scale computational study finds that protein misfolding may underlie a substantial share of hereditary hearing loss, reclassifying tens of ...

Researchers have developed an electroporation-based NMR method that delivers labeled proteins into intact mitochondria, enabling atomic-resolution observation of alpha-synuclein membrane ...

Researchers have discovered that the deubiquitinase USP12 stabilizes the Rab GTPase-activating protein TBC1D22A, activating PI3K-AKT-mTOR signaling and driving ovarian cancer ...

Researchers replaced toxic t-butanol with a menthol-octanoic acid deep eutectic solvent to purify tea membrane-bound polyphenol oxidase 17-fold, using molecular ...

In a pioneering breakthrough that could redefine therapeutic strategies for one of the most aggressive brain cancers, glioblastoma, researchers have ...